循环 DNA 起源于癌症患者的新范例。

A New Paradigm of the Origins of Circulating DNA in Patients with Cancer.

机构信息

IRCM, Montpellier Cancer Research Institute, INSERM U1194, Montpellier University, Montpellier, France.

ICM, Institut Régional du Cancer de Montpellier, Montpellier, France.

出版信息

Cancer Discov. 2023 Oct 5;13(10):2122-2124. doi: 10.1158/2159-8290.CD-23-0824.

DOI:10.1158/2159-8290.CD-23-0824

PMID:37794839

Abstract

By shedding light on the cellular origins of circulating DNA (cirDNA), this research provides important insights into the mechanisms of cirDNA production in cancer. Contrary to expectations, the increased cirDNA in patients with cancer was not derived predominantly from neoplastic cells or surrounding nonneoplastic epithelial cells; rather, the excess cirDNA originated primarily from leukocytes, implying a systemic impact of cancer on cell turnover or DNA clearance. See related article by Mattox et al., p. 2166 (1).

摘要

通过阐明循环 DNA（cirDNA）的细胞起源，这项研究为癌症中 cirDNA 产生的机制提供了重要的见解。与预期相反，癌症患者中增加的 cirDNA 主要不是来自肿瘤细胞或周围的非肿瘤上皮细胞；相反，多余的 cirDNA 主要来源于白细胞，这表明癌症对细胞更替或 DNA 清除有全身性影响。见 Mattox 等人的相关文章，第 2166 页（1）。