Department of Obstetrics and Gynaecology, Medical Research Center Oulu, Research Unit of Clinical Medicine, University of Oulu and Oulu University Hospital, Oulu, Finland.
Research Unit of Internal Medicine, Medical Research Center Oulu, University of Oulu and Oulu University Hospital, Oulu, Finland.
Ann Med. 2023;55(2):2264340. doi: 10.1080/07853890.2023.2264340. Epub 2023 Oct 5.
The aim of the study was to investigate are there associations between common female sex-specific health conditions (oligo/amenorrhea, hyperandrogenism, menopause and polycystic ovary syndrome [PCOS]) and high-sensitivity troponin-T (hs-TnT) levels.
Cross-sectional and longitudinal analyses of a general population-based prospective cohort study were performed. The hs-TnT levels of 3146 women aged 46 were measured using an Elecsys® Troponin T high-sensitivity assay. Median hs-TnT levels and 25 and 75 percentiles of the cases and controls were compared. Also, a logistic regression analysis using a binary outcome - undetectable hs-TnT (< 3.0 ng/L) versus detectable hs-TnT (≥ 3.0 ng/L) - was performed.
Women with oligo/amenorrhea at age 31 had significantly higher hs-TnT levels at age 46 than women without oligo/amenorrhea (4.06 [3.59; 4.86] vs 3.98 [3.44; 4.71] ng/L, = .042). Menopausal women had significantly higher hs-TnT levels than premenopausal women (4.15 [3.54; 4.91] vs 3.95 [3.45; 4.68] ng/L, = .012) at age 46. Women with PCOS or hyperandrogenism had comparable hs-TnT levels with their controls. In the adjusted logistic regression analysis, oligo/amenorrhea (odds ratio [OR] = 1.52 [0.90-2.57]), hyperandrogenism (OR = 1.20 [0.75-1.92]), PCOS (OR = 1.51 [0.81-2.84]) and menopause (OR = 1.05 [0.63-1.74]) were not significantly associated with detectable hs-TnT.
This study was the first to investigate how oligo/amenorrhea, hyperandrogenism, PCOS and menopause are associated with hs-TnT. Although women with oligo/amenorrhea and menopause had higher hs-TnT levels than women without these conditions, the difference was small. Larger studies are required to better understand the effects of oligo/amenorrhea on cardiovascular health.
本研究旨在探讨女性特有的常见健康状况（闭经/月经过少、高雄激素血症、绝经和多囊卵巢综合征[PCOS]）与高敏肌钙蛋白 T（hs-TnT）水平之间是否存在关联。
对一项基于一般人群的前瞻性队列研究进行了横断面和纵向分析。使用 Elecsys® Troponin T 高敏测定法测量了 3146 名 46 岁女性的 hs-TnT 水平。比较了病例和对照组中位数 hs-TnT 水平以及 25%和 75%分位数。还使用二项结局（不可检测的 hs-TnT（<3.0ng/L）与可检测的 hs-TnT（≥3.0ng/L））进行了逻辑回归分析。
31 岁时闭经/月经过少的女性，其 46 岁时的 hs-TnT 水平明显高于无闭经/月经过少的女性（4.06[3.59;4.86]vs3.98[3.44;4.71]ng/L， = .042）。绝经女性的 hs-TnT 水平明显高于绝经前女性（4.15[3.54;4.91]vs3.95[3.45;4.68]ng/L， = .012）。患有 PCOS 或高雄激素血症的女性与对照组的 hs-TnT 水平相当。在调整后的逻辑回归分析中，闭经/月经过少（比值比[OR] = 1.52[0.90-2.57]）、高雄激素血症（OR = 1.20[0.75-1.92]）、PCOS（OR = 1.51[0.81-2.84]）和绝经（OR = 1.05[0.63-1.74]）与可检测的 hs-TnT 无显著相关性。
本研究首次探讨了闭经/月经过少、高雄激素血症、PCOS 和绝经如何与 hs-TnT 相关。尽管闭经/月经过少和绝经的女性 hs-TnT 水平高于无这些情况的女性，但差异较小。需要更大规模的研究来更好地了解闭经/月经过少对心血管健康的影响。
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