Department of Gastroenterology, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, Qingdao, 266035, Shandong, China.
Department of Emergency General Surgery, the Affiliated Hospital of Qingdao University, Qingdao, 266000, Shandong, China.
Langenbecks Arch Surg. 2023 Oct 5;408(1):388. doi: 10.1007/s00423-023-03126-6.
Postoperative adhesions are frequent and significant complications that typically arise following abdominal surgery. Currently, the existing evidence for predicting the risk of adhesive small bowel obstruction (ASBO) after emergency gastrointestinal surgery (EGS) remains inadequate. A reliable perioperative model that quantifies the risk of ASBO after EGS serves as a practical tool for guiding individually tailored surveillance.
A consecutive series of 1296 patients who underwent EGS for radiologically confirmed bowel/visceral inflammation or perforation between 2012 and 2022 at a tertiary academic medical center were included in this study to establish a best-fit nomogram. The nomogram was externally validated by assessing discrimination and calibration using an independent cohort from a separate medical center.
A total of 116 patients (8.9%) developed at least one episode of ASBO after EGS during a median follow-up duration of 26 months. The results of multivariable logistic analysis indicated that male sex (P = 0.043), preoperative albumin level (P = 0.002), history of pelvic radiotherapy (P = 0.038), laparotomy (P = 0.044), and intensive care unit stay ≥ 72 h (P = 0.047) were identified as independent risk factors for developing ASBO. By incorporating these predictors, the developed nomogram exhibited good accuracy in risk estimation, as evidenced by a guide-corrected C-index score of 0.852 (95% CI 0.667-0.920) in the external validation cohort. Decision curve analysis and clinical impact curve demonstrated a clinically effective predictive model.
By incorporating the nomogram as a supplemental tool in perioperative management, it becomes possible to accurately assess the individual's likelihood of developing ASBOs. This quantification enables surgeons to implement appropriate preventive measures, ultimately leading to improved outcomes.
术后粘连是腹部手术后常见且严重的并发症。目前,预测急诊胃肠手术后粘连性小肠梗阻(ASBO)风险的现有证据仍然不足。一种可靠的围手术期模型,可以量化急诊胃肠手术后发生 ASBO 的风险,可作为指导个体化监测的实用工具。
本研究纳入了 2012 年至 2022 年期间在一家三级学术医疗中心因影像学证实的肠/内脏炎症或穿孔而行急诊胃肠手术的 1296 例连续患者,以建立最佳拟合列线图。使用来自另一家医疗中心的独立队列评估鉴别和校准,对外科列线图进行外部验证。
在中位随访 26 个月期间,共有 116 例(8.9%)患者在接受急诊胃肠手术后至少发生了一次 ASBO。多变量逻辑分析结果表明,男性(P=0.043)、术前白蛋白水平(P=0.002)、盆腔放疗史(P=0.038)、剖腹术(P=0.044)和重症监护病房住院时间≥72 小时(P=0.047)是发生 ASBO 的独立危险因素。通过纳入这些预测因素,开发的列线图在外部验证队列中表现出良好的准确性,指导校正 C 指数评分为 0.852(95%CI 0.667-0.920)。决策曲线分析和临床影响曲线表明该模型具有临床有效性。
通过将列线图作为围手术期管理的补充工具,可以准确评估个体发生 ASBO 的可能性。这种量化使外科医生能够实施适当的预防措施,最终改善结果。