Institute of College of Pharmacy, Changchun University of Traditional Chinese Medicine, 130117 Changchun, Jilin, China.
Ginseng Research Institute, Changchun University of Traditional Chinese Medicine, 130117 Changchun, Jilin, China.
Front Biosci (Landmark Ed). 2023 Sep 27;28(9):228. doi: 10.31083/j.fbl2809228.
Disorders of purine metabolism are the main cause of hyperuricemia. Current drugs for the treatment of hyperuricemia usually cause a degree of cardiovascular damage.
This study aimed to investigate the therapeutic effects of fruiting body (AFB), rhizomorph (AR) and fermentation product (after rhizomorphs removal) (AFP) on hyperuricemic mice. The hyperuricemia mouse model was established by oral administration of potassium oxonate 0.9 g⋅kg-1 and hypoxanthine 0.5 g⋅kg-1 for two weeks. Starting from the third week, the intragastric administration of the intervention drug group was as follows: Allopurinol 0.013 g⋅kg-1, AFB (3.9 and 7.8 g⋅kg-1), AR (3.9 and 7.8 g⋅kg-1), AFP (1.95 and 3.9 g⋅kg-1) once daily for 14 days.
Results showed that AFB, AR, and AFP reduced the contents of serum uric acid, serum creatinine, and blood urea nitrogen in hyperuricemic mice and the mechanism of action might be through up-regulation of the expression levels of organic anion transporter 1/organic anion transporter 3 proteins in kidney tissue. AR and AFP both exhibited better uric acid-lowering effects than AFB, which may be due to the higher purine content of AFB.
and its fermentation products can treat hyperuricemia by up-regulating OAT1 protein and OAT3 protein, reducing uric acid content in mice.
嘌呤代谢紊乱是引起高尿酸血症的主要原因。目前用于治疗高尿酸血症的药物通常会造成一定程度的心血管损伤。
本研究旨在探讨蛹虫草子实体（AFB）、菌核（AR）和发酵产物（去除菌核后）（AFP）对高尿酸血症小鼠的治疗作用。通过灌胃 0.9 g·kg-1 氧嗪酸钾和 0.5 g·kg-1 次黄嘌呤 2 周建立高尿酸血症小鼠模型。从第 3 周开始，干预药物组进行灌胃给药：别嘌醇 0.013 g·kg-1，AFB（3.9 和 7.8 g·kg-1），AR（3.9 和 7.8 g·kg-1），AFP（1.95 和 3.9 g·kg-1），每天 1 次，连续 14 天。
结果表明，AFB、AR 和 AFP 降低了高尿酸血症小鼠血清尿酸、血清肌酐和血尿素氮的含量，其作用机制可能是通过上调肾脏组织中有机阴离子转运蛋白 1/有机阴离子转运蛋白 3 蛋白的表达水平。AR 和 AFP 均表现出比 AFB 更好的降尿酸作用，这可能是由于 AFB 中嘌呤含量较高。
蛹虫草子实体及其发酵产物可以通过上调 OAT1 蛋白和 OAT3 蛋白来治疗高尿酸血症，降低小鼠体内尿酸含量。
