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小金蝠蛾感染冬虫夏草的早期组织病理学观察和比较转录组分析。

Histopathological observations and comparative transcriptome analysis of Ophiocordyceps sinensis infection of Hepialus xiaojinensis in the early stage.

机构信息

Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China, College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, China.

College of Medical Technology, Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, China; Chongqing Key Laboratory of Sichuan-Chongqing Co-construction for Diagnosis and Treatment of Infectious Diseases Integrated Traditional Chinese and Western Medicine, China.

出版信息

Dev Comp Immunol. 2024 Jan;150:105067. doi: 10.1016/j.dci.2023.105067. Epub 2023 Oct 4.

Abstract

Hepialus xiaojinensis is a Lepidopteran insect and one of the hosts for the artificial cultivation of Cordyceps. Ophiocordyceps sinensis can infect and coexist with H. xiaojinensis larvae for a long time. Little studies focused on the interaction process through its early infection stage. In this research, we particularly study the interaction of infected and uninfected larvae in the 3rd (OS-3, CK-3) and 4th (OS-4, CK-4) instars. O. sinensis was distributed within the larvae and accompanied by pathological changes in some tissue structures. In response to O. sinensis infection, OS-3 enhanced the antioxidant defense ability, while OS-4 decreased. The transcriptome analysis showed that OS-3 resisted the invasion of O. sinensis by the immune and nervous systems. Correspondingly, OS-4 reduced immune response and utilized more energy for growth and development. This study provides a comprehensive resource for analyzing the mechanism of H. xiaojinensis and O. sinensis interaction.

摘要

小金蝠蛾是鳞翅目昆虫,也是冬虫夏草人工养殖的宿主之一。中国被毛孢可长期感染并与小金蝠蛾幼虫共存。然而,目前很少有研究关注其早期感染阶段的相互作用过程。本研究特别研究了第 3 龄(OS-3,CK-3)和第 4 龄(OS-4,CK-4)幼虫中感染和未感染幼虫之间的相互作用。中国被毛孢分布在幼虫体内,并伴有一些组织结构的病理变化。OS-3 幼虫在面对中国被毛孢感染时,增强了抗氧化防御能力,而 OS-4 幼虫则降低了该能力。转录组分析表明,OS-3 通过免疫系统和神经系统来抵抗中国被毛孢的入侵。相应地,OS-4 减少了免疫反应,并为生长和发育利用了更多的能量。本研究为分析小金蝠蛾与中国被毛孢相互作用的机制提供了全面的资源。

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