State Key Laboratory of Environmental Criteria and Risk Assessment, National Engineering Laboratory for Lake Pollution Control and Ecological Restoration, State Environmental Protection Key Laboratory for Lake Pollution Control, Chinese Research Academy of Environmental Sciences, Beijing 100012, China; Northern Region Persistent Organic Pollution Control (NRPOP) Laboratory, Faculty of Engineering and Applied Science, Memorial University, St. John's, A1B 3X5, Canada.
State Key Laboratory of Environmental Criteria and Risk Assessment, National Engineering Laboratory for Lake Pollution Control and Ecological Restoration, State Environmental Protection Key Laboratory for Lake Pollution Control, Chinese Research Academy of Environmental Sciences, Beijing 100012, China.
Environ Pollut. 2023 Dec 1;338:122672. doi: 10.1016/j.envpol.2023.122672. Epub 2023 Oct 3.
Synthetic musks (SMs), the widely used odor component in personal care products have attracted attention due to their environmental impacts, especially the abortion risks. Given that women comprise a significant consumer demographic for personal care products, it is imperative to promptly initiate research on avoidance strategies for pregnant women concerning their exposure to synthetic chemicals (SMs). This study tried to establish novel theoretical approaches to eliminate the abortion risks of SM-contained body wash by designing the SM-contained proportioning scheme and analyzing the abortion risk mechanisms. The binding energy of SMs to estrogen-progesterone protein complex was used as an indicator of the abortion risk. A total of 324 SM-contained body wash proportioning schemes were designed using full factorial design and No. 218 was found as the most effective formula for body wash proportioning with the binding energy value of 68.6 kJ/mol. Results showed the abortion risk could be effectively alleviated (reduced 0.6%-163.4%) by regulating the proportioning scheme of SM-contained body wash. In addition, the mechanism analysis of SM-contained proportioning scheme proportioning scheme found that xanthan gum and disodium EDTA played essential roles in reducing the abortion risk in pregnant women after exposure. The selection of proper body wash components for reducing the abortion risk of SMs on pregnant women was first proposed. It sheds lights on the potential risks of people's daily life and proposes risk-eliminating strategies.
合成麝香（SMs）作为个人护理产品中广泛使用的气味成分，由于其对环境的影响而受到关注，尤其是对堕胎的风险。鉴于女性是个人护理产品的重要消费群体，当务之急是尽快研究孕妇避免接触合成化学品（SMs）的策略。本研究试图通过设计含有 SM 的沐浴露的配比方案并分析其堕胎风险机制，建立消除含有 SM 的沐浴露堕胎风险的新理论方法。SM 与雌孕激素蛋白复合物的结合能被用作衡量堕胎风险的指标。采用完全析因设计共设计了 324 种含有 SM 的沐浴露配比方案，发现编号为 218 的方案为最有效的配方，其结合能值为 68.6 kJ/mol。结果表明，通过调节含有 SM 的沐浴露的配比方案，堕胎风险可以得到有效缓解（降低 0.6%-163.4%）。此外，通过对含有 SM 的沐浴露配比方案的机制分析发现，黄原胶和 EDTA 二钠在降低孕妇暴露后的堕胎风险方面发挥了重要作用。首次提出选择适当的沐浴露成分来降低 SMs 对孕妇的堕胎风险。这揭示了人们日常生活中的潜在风险，并提出了风险消除策略。
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