Hebei Medical University, Hebei, China.
Affiliated Hospital of Chengde Medical University, Chengde, Hebei, China.
Medicine (Baltimore). 2023 Oct 6;102(40):e35406. doi: 10.1097/MD.0000000000035406.
Endometriosis is a chronic inflammatory, benign disorder that often co-occurs with adenomyosis and/or leiomyoma. The overall incidence of endometriosis in reproductive period women was nearly 10%. However, the exact mechanisms of endometriosis-associated pathogenesis are still unknown.
In this study, we aimed to investigate whether Frizzled-7 (FZD7) would effectively promote the development of endometriosis. The microarray-based data analysis was performed to screen endometriosis-related differentially expressed genes. This process uncovered specific hub genes, and the nexus of vital genes and ferroptosis-related genes were pinpointed. Then, we collected human endometrial and endometriotic tissues from patients with endometriosis of the ovary (n = 39) and control patients without endometriosis (n = 10, who underwent hysterectomy for uterine fibroids) to compare the expression of FZD7.
These findings indicated that the expression of FZD7 was high compared with normal endometrium, and FZD7 may promote the progression of endometriosis.
FZD7 may serve as a potential therapeutic target for endometriosis treatment.
子宫内膜异位症是一种慢性炎症性良性疾病，常与子宫腺肌病和/或子宫肌瘤并存。生育期妇女的子宫内膜异位症总发病率接近 10%。然而，子宫内膜异位症相关发病机制的确切机制仍不清楚。
本研究旨在探讨卷曲蛋白 7（FZD7）是否能有效促进子宫内膜异位症的发生。采用基于微阵列的数据分析筛选与子宫内膜异位症相关的差异表达基因。这一过程揭示了特定的枢纽基因，并确定了关键基因和铁死亡相关基因的交汇点。然后，我们收集了卵巢子宫内膜异位症患者（n=39）和无子宫内膜异位症的对照组患者（n=10，因子宫肌瘤行子宫切除术）的人子宫内膜和子宫内膜异位症组织，以比较 FZD7 的表达。
这些发现表明，FZD7 的表达与正常子宫内膜相比升高，FZD7 可能促进子宫内膜异位症的进展。
FZD7 可能成为子宫内膜异位症治疗的潜在治疗靶点。
