通过 Pickering 乳液法制备的抗菌聚乳酸，使用聚乙烯亚胺和聚多巴胺改性的纤维素纳米晶体作为乳化稳定剂。
Antibacterial polylactic acid fabricated via Pickering emulsion approach with polyethyleneimine and polydopamine modified cellulose nanocrystals as emulsion stabilizers.
机构信息
SCNU-TUE Joint Lab of Device Integrated Responsive Materials (DIRM), National Center for International Research on Green Optoelectronics, South China Normal University, Guangzhou 510006, China; Guangdong Provincial Key Laboratory of Optical Information Materials and Technology & Institute of Electronic Paper Displays, South China Academy of Advanced Optoelectronics, South China Normal University, Guangzhou 510006, China; ScienceK Ltd, Huzhou 313000, China.
SCNU-TUE Joint Lab of Device Integrated Responsive Materials (DIRM), National Center for International Research on Green Optoelectronics, South China Normal University, Guangzhou 510006, China; Guangdong Provincial Key Laboratory of Optical Information Materials and Technology & Institute of Electronic Paper Displays, South China Academy of Advanced Optoelectronics, South China Normal University, Guangzhou 510006, China.
出版信息
Int J Biol Macromol. 2023 Dec 31;253(Pt 5):127263. doi: 10.1016/j.ijbiomac.2023.127263. Epub 2023 Oct 4.
Antibacterial biodegradable plastics are highly demanded for food package and disposable medical plastic consumables. Incorporating antibacterial nanoagents into polymer matrices is an effective method to endow polymers with antibacterial activity. However, synthesis of sustainable antibacterial nanoagents with high antibacterial activity via facile approach and well dispersion of them in polymer matrices are still challenging. In this study, polyethyleneimine (PEI) was grafted on surface of cellulose nanocrystals (CNCs) via the oxidation self-polymerization of dopamine (DA) and the Michael addition/Schiff base reaction between DA and PEI. The resulted PEI and polydopamine modified CNCs (PPCs) showed substantially enhanced antibacterial activity and reduced cytotoxicity for NIH3T3 than PEI due to increased local concentration and anchoring of PEI. The minimum concentration of PPCs to achieve antibacterial rate of 99.99 % against S. aureus and E. coli were about 50 and 20 μg/mL, respectively. PPCs displayed outstanding emulsifying ability, and PPC coated polylactic acid (PLA) microspheres were obtained by drying PPC stabilized PLA Pickering emulsion, leading to a well dispersion of PPCs in PLA. PPC/PLA film prepared by hot-pressing displayed great antibacterial performance and enhanced mechanical properties. Therefore, this study proposed a facile approach to fabricate biocompatible antibacterial nanoagents and plastics.
抗菌可生物降解塑料在食品包装和一次性医用塑料耗材方面的需求很高。将抗菌纳米剂掺入聚合物基质中是赋予聚合物抗菌活性的有效方法。然而，通过简单的方法合成具有高抗菌活性的可持续抗菌纳米剂，并在聚合物基质中良好分散它们仍然具有挑战性。在本研究中，通过多巴胺（DA）的氧化自聚合和 DA 与 PEI 之间的迈克尔加成/席夫碱反应，将聚乙烯亚胺（PEI）接枝到纤维素纳米晶体（CNC）的表面上。所得的 PEI 和聚多巴胺修饰的 CNC（PPC）比 PEI 表现出更高的抗菌活性和更低的 NIH3T3 细胞毒性，这是由于 PEI 的局部浓度增加和固定。PPCs 对金黄色葡萄球菌和大肠杆菌的抗菌率达到 99.99%的最低浓度分别约为 50 和 20μg/mL。PPCs 显示出出色的乳化能力，通过干燥 PPC 稳定的 PLA Pickering 乳液，得到了 PPC 涂覆的聚乳酸（PLA）微球，从而使 PPC 在 PLA 中得到良好的分散。通过热压制备的 PPC/PLA 薄膜显示出良好的抗菌性能和增强的机械性能。因此，本研究提出了一种简单的方法来制备具有生物相容性的抗菌纳米剂和塑料。
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