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聚甲基丙烯酸甲酯/聚乳酸共混物的开发作为牙科应用的可持续生物材料。

Development of poly(methyl methacrylate)/poly(lactic acid) blend as sustainable biomaterial for dental applications.

机构信息

Dental Biomaterials Science, Graduate School, Chulalongkorn University, Bangkok, 10330, Thailand.

College of Dental Medicine, Rangsit University, Pathum Thani, 12000, Thailand.

出版信息

Sci Rep. 2023 Oct 6;13(1):16904. doi: 10.1038/s41598-023-44150-2.

DOI:10.1038/s41598-023-44150-2
PMID:37803035
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10558438/
Abstract

Poly(lactic acid) (PLA) is gaining popularity in manufacturing due to environmental concerns. When comparing to poly(methyl methacrylate) (PMMA), PLA exhibits low melting and glass transition temperature (T). To enhance the properties of these polymers, a PMMA/PLA blend has been introduced. This study aimed to investigate the optimal ratio of PMMA/PLA blends for potential dental applications based on their mechanical properties, physical properties, and biocompatibility. The PMMA/PLA blends were manufactured by melting and mixing using twin screw extruder and prepared into thermoplastic polymer beads. The specimens of neat PMMA (M100), three different ratios of PMMA/PLA blends (M75, M50, and M25), and neat PLA (M0) were fabricated with injection molding technique. The neat polymers and polymer blends were investigated in terms of flexural properties, T, miscibility, residual monomer, water sorption, water solubility, degradation, and biocompatibility. The data was statistically analyzed. The results indicated that T of PMMA/PLA blends was increased with increasing PMMA content. PMMA/PLA blends were miscible in all composition ratios. The flexural properties of polymer blends were superior to those of neat PMMA and neat PLA. The biocompatibility was not different among different composition ratios. Additionally, the other parameters of PMMA/PLA blends were improved as the PMMA ratio decreased. Thus, the optimum ratio of PMMA/PLA blends have the potential to serve as novel sustainable biomaterial for extensive dental applications.

摘要

聚乳酸（PLA）因其环境问题在制造业中越来越受欢迎。与聚甲基丙烯酸甲酯（PMMA）相比，PLA 的熔融和玻璃化转变温度（T）较低。为了提高这些聚合物的性能，已经引入了 PMMA/PLA 共混物。本研究旨在根据其机械性能、物理性能和生物相容性，研究 PMMA/PLA 共混物的最佳比例，以用于潜在的牙科应用。通过双螺杆挤出机熔融和混合制造 PMMA/PLA 共混物，并制备成热塑性聚合物珠粒。使用注塑成型技术制备纯 PMMA（M100）、三种不同比例的 PMMA/PLA 共混物（M75、M50 和 M25）和纯 PLA（M0）的样品。对纯聚合物和聚合物共混物进行了弯曲性能、T、混溶性、残留单体、吸水率、水溶性、降解和生物相容性的研究。对数据进行了统计分析。结果表明，随着 PMMA 含量的增加，PMMA/PLA 共混物的 T 增加。PMMA/PLA 共混物在所有组成比例下均具有混溶性。聚合物共混物的弯曲性能优于纯 PMMA 和纯 PLA。不同组成比例之间的生物相容性没有差异。此外，随着 PMMA 比例的降低，PMMA/PLA 共混物的其他参数也得到了改善。因此，PMMA/PLA 共混物的最佳比例有可能成为用于广泛牙科应用的新型可持续生物材料。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfa9/10558438/c8587e2b097e/41598_2023_44150_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfa9/10558438/dc6b175fe104/41598_2023_44150_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfa9/10558438/3d70607a612e/41598_2023_44150_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfa9/10558438/8b5a25b20e76/41598_2023_44150_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfa9/10558438/49feebf16749/41598_2023_44150_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfa9/10558438/42c71df235f9/41598_2023_44150_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfa9/10558438/07f4c16579c7/41598_2023_44150_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfa9/10558438/f89a4e9db683/41598_2023_44150_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfa9/10558438/c8587e2b097e/41598_2023_44150_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfa9/10558438/dc6b175fe104/41598_2023_44150_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfa9/10558438/3d70607a612e/41598_2023_44150_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfa9/10558438/8b5a25b20e76/41598_2023_44150_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfa9/10558438/49feebf16749/41598_2023_44150_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfa9/10558438/42c71df235f9/41598_2023_44150_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfa9/10558438/07f4c16579c7/41598_2023_44150_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfa9/10558438/f89a4e9db683/41598_2023_44150_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfa9/10558438/c8587e2b097e/41598_2023_44150_Fig8_HTML.jpg

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