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钆十年的保留与沉积：ESMRMB-GREC 瞻前顾后。

Ten years of gadolinium retention and deposition: ESMRMB-GREC looks backward and forward.

机构信息

Department of Radiology, C-2S, Leiden University Medical Center, Albinusdreef 2, NL-2333 ZA, Leiden, The Netherlands.

Centre for Medical Sciences CISMed, University of Trento, 38122, Trento, Italy.

出版信息

Eur Radiol. 2024 Jan;34(1):600-611. doi: 10.1007/s00330-023-10281-3. Epub 2023 Oct 7.

DOI:10.1007/s00330-023-10281-3
PMID:37804341
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10791848/
Abstract

In 2014, for the first time, visible hyperintensities on unenhanced T1-weighted images in the nucleus dentatus and globus pallidus of the brain were associated with previous Gadolinium-based contrast agent (GBCA) injections and gadolinium deposition in patients with normal renal function. This led to a frenzy of retrospective studies with varying methodologies that the European Society of Magnetic Resonance in Medicine and Biology Gadolinium Research and Educational Committee (ESMRMB-GREC) summarised in 2019. Now, after 10 years, the members of the ESMRMB-GREC look backward and forward and review the current state of knowledge of gadolinium retention and deposition. CLINICAL RELEVANCE STATEMENT: Gadolinium deposition is associated with the use of linear GBCA but no clinical symptoms have been associated with gadolinium deposition. KEY POINTS : • Traces of Gadolinium-based contrast agent-derived gadolinium can be retained in multiple organs for a prolonged time. • Gadolinium deposition is associated with the use of linear Gadolinium-based contrast agents. • No clinical symptoms have been associated with gadolinium deposition.

摘要

2014 年，首次在肾功能正常的患者中发现脑内齿状核和苍白球的未增强 T1 加权图像上出现可见的高信号，与之前使用钆基造影剂（GBCA）注射和钆沉积有关。这导致了一系列回顾性研究的热潮，研究方法各不相同，欧洲磁共振医学与生物学学会（ESMRMB）的钆研究和教育委员会（Gadolinium Research and Educational Committee，GREC）在 2019 年对此进行了总结。现在，10 年过去了，ESMRMB-GREC 的成员回顾过去，展望未来，回顾了目前对钆保留和沉积的认识现状。临床相关性：钆沉积与线性 GBCA 的使用有关，但尚未发现与钆沉积有关的临床症状。要点：

  • 痕量的基于钆的造影剂衍生的钆可以在多个器官中长时间保留。
  • 钆沉积与线性钆基造影剂的使用有关。
  • 尚未发现与钆沉积有关的临床症状。
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a2c/10791848/38b2fb27601b/330_2023_10281_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a2c/10791848/6ff683b83500/330_2023_10281_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a2c/10791848/d195f785a1f3/330_2023_10281_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a2c/10791848/56bb7e63f976/330_2023_10281_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a2c/10791848/38b2fb27601b/330_2023_10281_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a2c/10791848/6ff683b83500/330_2023_10281_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a2c/10791848/d195f785a1f3/330_2023_10281_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a2c/10791848/56bb7e63f976/330_2023_10281_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a2c/10791848/38b2fb27601b/330_2023_10281_Fig4_HTML.jpg

相似文献

[1]
Ten years of gadolinium retention and deposition: ESMRMB-GREC looks backward and forward.

Eur Radiol. 2024-1

[2]
Pediatric Brain: Gadolinium Deposition in Dentate Nucleus and Globus Pallidus on Unenhanced T1-Weighted Images Is Dependent on the Type of Contrast Agent.

Invest Radiol. 2018-4

[3]
Progressive T1 Shortening of the Dentate Nucleus in Patients With Multiple Sclerosis: Result of Multiple Administrations of Linear Gadolinium Contrast Agents Versus Intrinsic Disease.

AJR Am J Roentgenol. 2018-8-30

[4]
Gadolinium deposition within the paediatric brain: no increased intrinsic T1-weighted signal intensity within the dentate nucleus following the administration of a minimum of four doses of the macrocyclic agent gadobutrol.

Eur Radiol. 2018-5-9

[5]
Increased signal intensities in the dentate nucleus and globus pallidus on unenhanced T1-weighted images: evidence in children undergoing multiple gadolinium MRI exams.

Pediatr Radiol. 2016-10

[6]
High Signal Intensity in the Dentate Nucleus and Globus Pallidus on Unenhanced T1-Weighted MR Images: Comparison between Gadobutrol and Linear Gadolinium-Based Contrast Agents.

AJNR Am J Neuroradiol. 2018-2-1

[7]
High Signal Intensity in Dentate Nucleus on Unenhanced T1-weighted MR Images: Association with Linear versus Macrocyclic Gadolinium Chelate Administration.

Radiology. 2015-1-27

[8]
Signal intensity at unenhanced T1-weighted magnetic resonance in the globus pallidus and dentate nucleus after serial administrations of a macrocyclic gadolinium-based contrast agent in children.

Pediatr Radiol. 2017-9

[9]
Increasing signal intensity within the dentate nucleus and globus pallidus on unenhanced T1W magnetic resonance images in patients with relapsing-remitting multiple sclerosis: correlation with cumulative dose of a macrocyclic gadolinium-based contrast agent, gadobutrol.

Eur Radiol. 2016-3

[10]
Effect of Renal Function on Gadolinium-Related Signal Increases on Unenhanced T1-Weighted Brain Magnetic Resonance Imaging.

Invest Radiol. 2016-11

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[2]
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[3]
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[4]
From routine to selective: how updated MRI guidelines reshape gadolinium use in Germany.

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[5]
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[6]
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[7]
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[8]
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[9]
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[10]
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本文引用的文献

[1]
Safe use of contrast media in myasthenia gravis: systematic review and updated European Society of Urogenital Radiology Contrast Media Safety Committee guidelines.

Eur Radiol. 2024-7

[2]
MR Imaging Signs of Gadolinium Retention Are Not Associated with Long-Term Motor and Cognitive Outcomes in Multiple Sclerosis.

AJNR Am J Neuroradiol. 2023-4

[3]
Gadolinium retention in a rat model of subtotal renal failure: are there differences among macrocyclic GBCAs?

Eur Radiol Exp. 2023-3-1

[4]
Skin Thickening of the Scalp and High Signal Intensity of Dentate Nucleus in Multiple Sclerosis: Association With Linear Versus Macrocyclic Gadolinium-Based Contrast Agents Administration.

Invest Radiol. 2023-3-1

[5]
Quantitative Susceptibility Mapping: Basic Methods and Clinical Applications.

Radiographics. 2022

[6]
Effects of chemical forms of gadolinium on the spleen in mice after single intravenous administration.

Biochem Biophys Rep. 2022-1-28

[7]
Comprehensive Speciation Analysis of Residual Gadolinium in Deep Cerebellar Nuclei in Rats Repeatedly Administered With Gadoterate Meglumine or Gadodiamide.

Invest Radiol. 2022-5-1

[8]
Neurologic Effects of Gadolinium Retention in the Brain after Gadolinium-based Contrast Agent Administration.

Radiology. 2022-3

[9]
An NMR relaxometry approach for quantitative investigation of the transchelation of gadolinium ions from GBCAs to a competing macromolecular chelator.

Sci Rep. 2021-11-5

[10]
Dentate-nucleus gadolinium deposition on magnetic resonance imaging: ultrasonographic and clinical correlates in multiple sclerosis patients.

Neurol Sci. 2022-4

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