Seyedaghamiri Fatemehsadat, Geranmayeh Mohammad Hossein, Ghadiri Tahereh, Ebrahimi-Kalan Abbas, Hosseini Leila
Department of Neuroscience, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Acta Neurol Belg. 2024 Jun;124(3):767-774. doi: 10.1007/s13760-023-02391-y. Epub 2023 Oct 7.
The functional structure of the blood-brain barrier (BBB) deteriorates after stroke by developing diffuse microvascular and neurovascular dysfunction and loss of white matter integrity. This causes nervous tissue injury and causes sensory and motor disabilities in stroke patients. Improving the integrity of the BBB and neurovascular remodeling after stroke can promote post-stroke injury conditions. Pericytes are contractile cells abundant in the BBB and sandwiched between astrocytes and endothelial cells of the microvessels. Stroke could lead to the degeneration of pericytes in the BBB. However, recent evidence shows that promoting pericytes enhances BBB integrity and neurovascular remodeling. Furthermore, pericytes achieve multipotent properties under hypoxic conditions, allowing them to transdifferentiate into the brain resident cells such as microglia. Microglia regulate immunity and inflammatory response after stroke. The current review studies recent findings in the intervening mechanisms underlying the regulatory effect of pericytes in BBB recovery after stroke.
中风后，血脑屏障（BBB）的功能结构会因弥漫性微血管和神经血管功能障碍以及白质完整性丧失而恶化。这会导致神经组织损伤，并导致中风患者出现感觉和运动障碍。改善中风后血脑屏障的完整性和神经血管重塑可以促进中风后的损伤恢复。周细胞是血脑屏障中丰富的收缩细胞，夹在星形胶质细胞和微血管内皮细胞之间。中风可能导致血脑屏障中的周细胞退化。然而，最近的证据表明，促进周细胞可增强血脑屏障的完整性和神经血管重塑。此外，周细胞在缺氧条件下具有多能特性，使其能够转分化为脑内驻留细胞，如小胶质细胞。小胶质细胞调节中风后的免疫和炎症反应。本综述研究了周细胞对中风后血脑屏障恢复的调节作用的干预机制的最新发现。
