帕金森病患者站立时血清去甲肾上腺素的反应。

Serum noradrenaline response to standing up in patients with Parkinson's disease.

作者信息

Turkka J T, Juujärvi K K, Lapinlampi T O, Myllylä V V

出版信息

Eur Neurol. 1986;25(5):355-61. doi: 10.1159/000116034.

Abstract

Responses of serum noradrenaline (NA) levels to standing up were determined in patients with Parkinson's disease (PD) examining 15 patients and 13 healthy subjects of similar age in order to obtain information about autonomic failure in PD. Mild symptoms of autonomic dysfunction were found in all the patients. The mean (+/- SD) increment of serum NA levels as a response to standing up of patients was 0.11 +/- 0.29 nmol/l and that of the controls 1.09 +/- 1.15, the percentage rises being 5.4 +/- 12.1 and 38.2 +/- 35.0, respectively. These results indicate that serum NA responses to standing up in patients with PD are significantly diminished describing a sympathetic nervous system deficit in PD.

摘要

为了获取帕金森病（PD）自主神经功能衰竭的相关信息，对15例帕金森病患者和13名年龄相仿的健康受试者进行了研究，测定了血清去甲肾上腺素（NA）水平对站立的反应。所有患者均发现有轻度自主神经功能障碍症状。患者站立后血清NA水平的平均（±标准差）增加值为0.11±0.29 nmol/L，对照组为1.09±1.15，百分比升高分别为5.4±12.1和38.2±35.0。这些结果表明，帕金森病患者站立时血清NA反应明显减弱，提示帕金森病存在交感神经系统缺陷。