间歇性低氧血症对早产儿1型早产儿视网膜病变的影响。

The Impact of Intermittent Hypoxemia on Type 1 Retinopathy of Prematurity in Preterm Infants.

作者信息

Haratbar Samaneh Rabienia, Chen Li, Cheng Qiang, Singh Dara, Fathi Faraneh, Mohtasebi Mehrana, Liu Xuhui, Patwardhan Abhijit, Bhandary Prasad, Bada Henrietta S, Yu Guoqiang, Abu Jawdeh Elie G

机构信息

Department of Biomedical Engineering, University of Kentucky.

Biostatistics and Bioinformatics Shared Resource Facility, Markey Cancer Center, University of Kentucky.

出版信息

medRxiv. 2023 Sep 26:2023.09.25.23295922. doi: 10.1101/2023.09.25.23295922.

DOI:10.1101/2023.09.25.23295922

PMID:37808800

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10557831/

Abstract

BACKGROUND

Intermittent hypoxemia (IH) may influence retinopathy of prematurity (ROP) development in preterm infants, however, previous studies had mixed results. This study aims to assess the influence and evaluate the predictive ability of IH measures on Type 1 ROP, a stage beyond which ROP treatment is indicated.

METHODS

IH was quantified by continuously monitoring oxygen saturation (SpO) using high-resolution pulse oximeters during the first 10 weeks of life. Statistical analyses assessed the relationship and predictive ability of weekly and cumulative IH variables for Type 1 ROP development.

RESULTS

Univariate analyses suggested that IH measures are greater in infants with Type 1 ROP and are predictive of Type 1 ROP development. Multivariable logistic regression analyses revealed that cumulative IH of longer duration during certain postnatal periods are associated with Type 1 ROP development after adjusting for gestational age (GA) or birth weight (BW). Although area under the curve (AUC) analyses revealed added predictivity of cumulative IH variables above GA or BW, these increments in AUC were not statistically significant.

CONCLUSIONS

The duration of IH events was associated with Type 1 ROP development. Interventions for reducing the duration of IH events may potentially improve ROP outcomes.

摘要

背景

间歇性低氧血症（IH）可能会影响早产儿视网膜病变（ROP）的发展，然而，先前的研究结果不一。本研究旨在评估IH指标对1型ROP的影响，并评估其预测能力，1型ROP是一个需要进行ROP治疗的阶段。

方法

在出生后的前10周内，使用高分辨率脉搏血氧仪连续监测血氧饱和度（SpO）来量化IH。统计分析评估了每周和累积IH变量与1型ROP发展之间的关系及预测能力。

结果

单因素分析表明，1型ROP婴儿的IH指标更高，且可预测1型ROP的发展。多变量逻辑回归分析显示，在调整胎龄（GA）或出生体重（BW）后，出生后某些时期持续时间较长的累积IH与1型ROP发展相关。尽管曲线下面积（AUC）分析显示累积IH变量比GA或BW具有更高的预测性，但AUC的这些增加在统计学上并不显著。