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XanFur,一种由 HO 诱导的新型 Fur 蛋白,受到全局转录调节因子 Clp 的正向调控,是 pv. 在水稻中完全毒力所必需的。

XanFur, a novel Fur protein induced by HO, positively regulated by the global transcriptional regulator Clp and required for the full virulence of pv. in rice.

机构信息

Institute of Plant Protection, Jiangsu Academy of Agricultural Sciences , Nanjing, Jiangsu, China.

State Key Laboratory of Microbial Technology, Shandong University , Qingdao, Shandong, China.

出版信息

Microbiol Spectr. 2023 Dec 12;11(6):e0118723. doi: 10.1128/spectrum.01187-23. Epub 2023 Oct 13.

Abstract

Although pv. () has been found to be a bacterial pathogen causing bacterial leaf blight in rice for many years, the molecular mechanisms of the rice- interaction has not been fully understood. In this study, we found that XanFur of is a novel ferric uptake regulator (Fur) protein conserved among major pathogenic species. XanFur is required for the virulence of in rice, and likely involved in regulating the virulence determinants of . The expression of is induced by HO, and positively regulated by the global transcriptional regulator Clp. Our results reveal the function and regulation of the novel virulence-related Fur protein XanFur in providing new insights into the interaction mechanisms of rice-.

摘要

虽然 pv. () 多年来一直被认为是导致水稻细菌性叶斑病的细菌病原体,但水稻-相互作用的分子机制尚未完全理解。在这项研究中,我们发现 中的 XanFur 是一种新型的铁摄取调节剂(Fur)蛋白,在主要致病性 物种中保守。XanFur 是 的在水稻中的毒力所必需的,并且可能参与调节 的毒力决定因素。 的表达受 HO 诱导,并受全局转录调节剂 Clp 正向调控。我们的结果揭示了新型与毒力相关的 Fur 蛋白 XanFur 在 中的功能和调节作用,为水稻-的相互作用机制提供了新的见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97e9/10714925/ec759210a7fb/spectrum.01187-23.f001.jpg

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