Hunan Gynecological Tumor Clinical Research Center; Hunan Key Laboratory of Cancer Metabolism; Hunan Cancer Hospital, and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha 410008, PR China.
Department of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, and National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, PR China; Institute of Clinical Pharmacology, Engineering Research Center for Applied Technology of Pharmacogenomics of Ministry of Education, Central South University, Changsha 410078, PR China.
Biochem Pharmacol. 2023 Nov;217:115857. doi: 10.1016/j.bcp.2023.115857. Epub 2023 Oct 13.
Ovarian cancer stands as the prevailing gynecologic malignancy, afflicting over 313,959 individuals annually worldwide, accompanied by more than 207,252 fatalities. Perturbations in calcium signaling contribute significantly to the pathogenesis of numerous cancers, including ovarian cancer, wherein alterations in calcium transporter expression have been reported. Overexpression of TRPM7, a prominent calcium transporter, has been linked to adverse prognostic outcomes in various cancer types. The focus of this comprehensive review centers around delineating the oncogenic role of TRPM7 in cancer development and exploring its therapeutic potential as a target in combating this disease. Notably, TRPM7 fosters cancer invasion, metastasis, and uncontrolled cell proliferation, thereby perpetuating the expansion and reinforcement of these malignant entities. Furthermore, this review takes ovarian cancer as an example and summarizes the "dual-mode" regulatory role of TRPM7 in cancer. Within the domain of ovarian cancer, TRPM7 assumes the role of a harsh tyrant, firmly controlling the calcium ion signaling pathway and metabolic reprogramming pathways.
卵巢癌是一种常见的妇科恶性肿瘤，全球每年有超过 313959 人患病，超过 207252 人死亡。钙信号的紊乱对包括卵巢癌在内的许多癌症的发病机制有重要影响，已有报道称钙转运体的表达发生改变。钙转运体 TRPM7 的过度表达与多种癌症类型的不良预后结果有关。本综述的重点是阐述 TRPM7 在癌症发展中的致癌作用，并探讨其作为治疗靶点在对抗这种疾病方面的潜在应用。值得注意的是，TRPM7 促进了癌症的侵袭、转移和不受控制的细胞增殖，从而使这些恶性实体不断扩大和强化。此外，本综述以卵巢癌为例，总结了 TRPM7 在癌症中的“双重模式”调节作用。在卵巢癌中，TRPM7 扮演着暴君的角色，牢牢控制着钙离子信号通路和代谢重编程通路。
