The First Affiliated Hospital, School of Medicine, Zhejiang University, 310006, Hangzhou, China; MOE Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang, ZJ310058, China.
Center for Comparative Biomedicine, Ministry of Education Key Laboratory of Systems Biomedicine, State Key Laboratory of Systems Medicine for Cancer, Institute of Systems Biomedicine, Shanghai Jiao Tong University, Shanghai 200240, China.
Trends Biochem Sci. 2023 Dec;48(12):1044-1057. doi: 10.1016/j.tibs.2023.09.001. Epub 2023 Oct 13.
The ability of neurites of the same neuron to avoid each other (self-avoidance) is a conserved feature in both invertebrates and vertebrates. The key to self-avoidance is the generation of a unique subset of cell-surface proteins in individual neurons engaging in isoform-specific homophilic interactions that drive neurite repulsion rather than adhesion. Among these cell-surface proteins are fly Dscam1 and vertebrate clustered protocadherins (cPcdhs), as well as the recently characterized shortened Dscam (sDscam) in the Chelicerata. Herein, we review recent advances in our understanding of how cPcdh, Dscam, and sDscam cell-surface recognition codes are expressed and translated into cellular functions essential for neural wiring.
同一神经元的神经突彼此回避的能力（自我回避）是无脊椎动物和脊椎动物共有的保守特征。自我回避的关键是在个体神经元中产生一组独特的细胞表面蛋白亚群，这些蛋白亚群参与同种型特异性的同源相互作用，从而驱动神经突排斥而不是粘附。这些细胞表面蛋白包括果蝇 Dscam1 和脊椎动物聚集原钙黏蛋白（cPcdhs），以及最近在螯肢动物中被描述的缩短的 Dscam（sDscam）。本文综述了我们对 cPcdh、Dscam 和 sDscam 细胞表面识别码的表达及其转化为神经布线所必需的细胞功能的理解的最新进展。
