Department of Cardiovascular Surgery, Kumamoto University Hospital, Kumamoto, Japan.
Asian Cardiovasc Thorac Ann. 2023 Nov;31(9):775-780. doi: 10.1177/02184923231206237. Epub 2023 Oct 16.
This study aimed to examine the clinical outcomes of mitral valve replacement (MVR) in patients with severe mitral annular calcification (MAC) who required extensive decalcification and mitral annular reconstruction.
We reviewed 15 patients with severe MAC who underwent MVR between January 2016 and May 2022. In all cases, the calcified mitral annulus was resected completely using a Cavitron Ultrasound Surgical Aspirator, and a new annulus was created using bovine pericardium. In the acute postoperative phase, strict afterload reduction therapy using an intra-aortic balloon pump (IABP) was administered.
The mean age of patients was 73 ± 8 years, and 13 (86.7%) were women. Concomitant aortic valve replacement was performed in 11 (73.3%) patients, tricuspid annuloplasty in 9 (60.0%), coronary artery bypass grafting in 1 (6.7%), and arrhythmia surgery in 7 (46.7%). The mean aortic cross-clamp and cardiopulmonary bypass times were 143 ± 32 min and 175 ± 34 min, respectively. In 13 patients, an IABP was used for 2 or 3 days postoperatively. There were no in-hospital deaths, left ventricular ruptures, or other MAC-related complications. Postoperative echocardiography revealed no paravalvular leakages.
Our strategy for managing severe MAC is safe and reproducible even in relatively high-risk patients. Afterload reduction using an IABP in the acute postoperative phase may reduce the risk of fatal complications after extensive decalcification and mitral annular reconstruction.
本研究旨在探讨需要广泛去钙化和二尖瓣环重建的重度二尖瓣环钙化(MAC)患者行二尖瓣置换术(MVR)的临床结果。
我们回顾了 2016 年 1 月至 2022 年 5 月期间 15 例接受 MVR 的重度 MAC 患者。所有患者均使用 Cavitron Ultrasound Surgical Aspirator 完全切除钙化的二尖瓣环,并使用牛心包构建新的瓣环。在急性术后阶段,使用主动脉内球囊泵(IABP)进行严格的后负荷降低治疗。
患者的平均年龄为 73 ± 8 岁,13 例(86.7%)为女性。11 例(73.3%)患者同期行主动脉瓣置换术,9 例(60.0%)行三尖瓣环成形术,1 例(6.7%)行冠状动脉旁路移植术,7 例(46.7%)行心律失常手术。主动脉阻断和体外循环时间的平均值分别为 143 ± 32 min 和 175 ± 34 min。13 例患者术后使用 IABP 2-3 天。无院内死亡、左心室破裂或其他 MAC 相关并发症。术后超声心动图显示无瓣周漏。
即使在高危患者中,我们处理重度 MAC 的策略也是安全且可重复的。在急性术后阶段使用 IABP 降低后负荷可能会降低广泛去钙化和二尖瓣环重建后致命并发症的风险。