Department of Orthopaedics, The Second Hospital of Shanxi Medical University, Taiyuan, China.
Shanxi Key Laboratory of Bone and Soft Tissue Injury Repair, Taiyuan, China.
Cartilage. 2024 Sep;15(3):209-218. doi: 10.1177/19476035231205695. Epub 2023 Oct 18.
To evaluate the clinical characteristics and global trends in the surgical treatment of articular cartilage defects.
Studies in English published between January 1, 2001 and December 31, 2020 were retrieved from MEDLINE, WOS, INSPEC, SCIELO, KJD, and RSCI on the "Web of Science." Patient data were extracted, including age, sex, defect location and laterality, duration of follow-up and symptoms, and body mass index (BMI). Data were further stratified according to the surgical method, lesion location, procedural type and geographical area, and time period. A comparative analysis was performed.
Overall, 443 studies involving 26,854 patients (mean age, 35.25 years; men, 60.5%) were included. The mean lesion size and patient BMI were 3.51 cm and 25.61 kg/m, respectively. Cartilage defects at the knees, talus, and hips affected 20,850 (77.64%), 3,983 (14.83%), and 1,425 (5.31%) patients, respectively. The numbers of patients who underwent autologous chondrocyte implantation, arthroscopic debridement/chondroplasty, osteochondral allograft (OCA), osteochondral autologous transplantation, and microfracture were 7,114 (26.49%), 5,056 (18.83%), 3,942 (14.68%), 3,766 (14.02%), and 2,835 (10.56%), respectively. European patients were the most numerous and youngest. North American patients had the largest defects. The number of patients increased from 305 in 2001 to 3,017 in 2020. In the last 5 years, the frequency of OCAs showed a greatly increasing trend.
Clinical characteristics and global trends in the surgical treatment of articular cartilage defects were revealed. The choice of operation should be based on the patient characteristics and defect location, size, and shape, as well as the patient's preference.
评估关节软骨缺损的手术治疗的临床特点和全球趋势。
检索 2001 年 1 月 1 日至 2020 年 12 月 31 日在 MEDLINE、WOS、INSPEC、SCIELO、KJD 和 RSCI 的英文文献，提取患者数据，包括年龄、性别、缺陷位置和侧别、随访时间和症状以及体重指数（BMI）。根据手术方法、病变位置、手术类型和地理区域以及时间段对数据进行进一步分层，并进行比较分析。
共纳入 443 项研究，涉及 26854 例患者（平均年龄 35.25 岁，男性 60.5%）。平均病变大小和患者 BMI 分别为 3.51cm 和 25.61kg/m。膝关节、距骨和髋关节软骨缺损分别影响 20850（77.64%）、3983（14.83%）和 1425（5.31%）例患者。接受自体软骨细胞移植、关节镜下清创/软骨成形术、骨软骨同种异体移植物（OCA）、骨软骨自体移植和微骨折的患者分别为 7114（26.49%）、5056（18.83%）、3942（14.68%）、3766（14.02%）和 2835（10.56%）例。欧洲患者数量最多，年龄最小。北美患者的缺陷最大。患者数量从 2001 年的 305 例增加到 2020 年的 3017 例。在过去 5 年中，OCA 的频率呈现出显著增加的趋势。
揭示了关节软骨缺损的手术治疗的临床特点和全球趋势。手术选择应根据患者特征以及缺陷的位置、大小和形状，以及患者的偏好。
