Modak Baishakhi, Solomon Monica C, Karmakar Shaswata, Polley Shreyasi
Department of Oral and Maxillofacial Pathology and Oral Microbiology, Manipal College of Dental Sciences, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Department of Periodontology, Manipal College of Dental Sciences, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India.
J Oral Maxillofac Pathol. 2023 Apr-Jun;27(2):390-395. doi: 10.4103/jomfp.jomfp_46_23. Epub 2023 Jul 13.
Oral cancer or oral squamous cell carcinoma comprises more than three-fourth of all the malignant neoplasms of the oral cavity. Worldwide, it is the 18 most common malignancy. The patients suffering from cancer usually remains immune to the standard therapies such as surgical resection of tumours, radiotherapy and chemotherapy; however, there can be probabilities of chronic and acute toxicities and secondary malignancies as well. Recently, has been introduced in the arena of biomedicine to improve the treatment modality for oral malignant and potentially malignant disorders. It replaces the defective gene followed by repairing by a therapeutic gene. Gene therapy can attack cancerous cells without causing harmful effect to the normal tissue. It is useful to cope with the relapse of diseases and as a synergetic treatment. The present article reviewed the types of gene therapy, modes of delivery of the therapeutic genes and different techniques used along with pros and cons of gene therapy.
口腔癌或口腔鳞状细胞癌占口腔所有恶性肿瘤的四分之三以上。在全球范围内，它是第18种最常见的恶性肿瘤。患有癌症的患者通常对标准治疗方法如肿瘤手术切除、放疗和化疗免疫；然而，也可能存在慢性和急性毒性以及继发性恶性肿瘤的可能性。最近，生物医学领域引入了基因疗法以改善口腔恶性和潜在恶性疾病的治疗方式。它替换有缺陷的基因，然后用治疗性基因进行修复。基因疗法可以攻击癌细胞而不对正常组织造成有害影响。它有助于应对疾病复发并作为一种协同治疗方法。本文综述了基因疗法的类型、治疗性基因的递送方式以及所使用的不同技术，以及基因疗法的优缺点。
