Meza U, Romero-Méndez C, Sánchez-Armáss S, Rodríguez-Menchaca A A
Departamento de Fisiología y Biofísica, Facultad de Medicina, Universidad Autónoma de San Luis Potosí, San Luis Potosí, México.
Neurologia (Engl Ed). 2023 Nov-Dec;38(9):671-680. doi: 10.1016/j.nrleng.2023.10.003. Epub 2023 Oct 17.
Rafts are protein-lipid structural nanodomains involved in efficient signal transduction and the modulation of physiological processes of the cell plasma membrane. Raft disruption in the nervous system has been associated with a wide range of disorders.
We review the concept of rafts, the nervous system processes in which they are involved, and their role in diseases such as Parkinson's disease, Alzheimer disease, and Huntington disease.
Based on the available evidence, preservation and/or reconstitution of rafts is a promising treatment strategy for a wide range of neurological disorders.
脂筏是蛋白质-脂质结构纳米域，参与细胞浆膜的高效信号转导和生理过程调节。神经系统中的脂筏破坏与多种疾病相关。
我们综述了脂筏的概念、它们所涉及的神经系统过程以及它们在帕金森病、阿尔茨海默病和亨廷顿病等疾病中的作用。
基于现有证据，脂筏的保存和/或重建是治疗多种神经疾病的一种有前景的策略。
