Shramko V S, Shcherbakova L V, Kashtanova E V, Stakhneva E M, Polonskaya Ya V, Ragino Yu I
Research Institute of Internal and Preventive Medicine - Branch of Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.
Bull Exp Biol Med. 2023 Sep;175(5):629-632. doi: 10.1007/s10517-023-05915-x. Epub 2023 Oct 20.
The content of individual unsaturated fatty acids in blood plasma (measured by HPLC) and their association with abdominal obesity in a group of men (mean age 52.2 years) was analyzed. The abdominal obesity was diagnosed according to the criteria of the All-Russian Scientific Society of Cardiology (waist circumference >94 cm). Men with abdominal obesity had higher levels of ω-6 γ-linolenic and dihomo-γ-linolenic acids, as well as ω-3 eicosapentaenoic and docosahexaenoic acids. They also had significantly elevated plasma levels of triglycerides and glucose and lower levels of HDL. Using single-factor ROC analysis we determined optimal cut-off thresholds for fatty acid levels indicating the presence of abdominal obesity. The results of regression analysis showed that the level of γ-linolenic acid is directly associated with the chance of abdominal obesity.s.
分析了一组男性（平均年龄52.2岁）血浆中单个不饱和脂肪酸的含量（通过高效液相色谱法测定）及其与腹部肥胖的关联。根据全俄心脏病科学学会的标准（腰围>94厘米）诊断腹部肥胖。腹部肥胖的男性ω-6γ-亚麻酸和二高-γ-亚麻酸以及ω-3二十碳五烯酸和二十二碳六烯酸水平较高。他们的血浆甘油三酯和葡萄糖水平也显著升高，而高密度脂蛋白水平较低。使用单因素ROC分析，我们确定了表明存在腹部肥胖的脂肪酸水平的最佳截断阈值。回归分析结果表明，γ-亚麻酸水平与腹部肥胖的几率直接相关。
