髓系肿瘤中浆细胞样树突状细胞的扩增：髓系肿瘤的一个新的独特亚群？

Plasmacytoid dendritic cell expansion in myeloid neoplasms: A novel distinct subset of myeloid neoplasm?

机构信息

Department of Hematology, Tongji Hospital, Tongji Medical college, Huazhong University of Science and Technology, Wuhan 430000, Hubei, China; Immunotherapy Research Center for Hematologic Diseases of Hubei Province, Wuhan, Hubei 430030, China.

Department of Hematology, Tongji Hospital, Tongji Medical college, Huazhong University of Science and Technology, Wuhan 430000, Hubei, China; Department of Hematology, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan 030032, China.

出版信息

Crit Rev Oncol Hematol. 2023 Dec;192:104186. doi: 10.1016/j.critrevonc.2023.104186. Epub 2023 Oct 18.

DOI:10.1016/j.critrevonc.2023.104186

PMID:37863402

Abstract

Plasmacytoid dendritic cells (pDCs) are a specific dendritic cell type stemming from the myeloid lineage. Clinically and pathologically, neoplasms associated with pDCs are classified as blastic plasmacytoid dendritic cell neoplasm (BPDCN), mature plasmacytoid dendritic myeloid neoplasm (MPDMN) and pDC expansion in myeloid neoplasms (MNs). BPDCN was considered a rare and aggressive neoplasm in the 2016 World Health Organization (WHO) classification. MPDMN, known as mature pDC-derived neoplasm, is closely related to MNs and was first recognized in the latest 2022 WHO classification, proposing a new concept that acute myeloid leukemia cases could show clonally expanded pDCs (pDC-AML). With the advances in detection techniques, an increasing number of pDC expansion in MNs have been reported, but whether the pathogenesis is similar to that of MPDMN remains unclear. This review focuses on patient characteristics, diagnosis and treatment of pDC expansion in MNs to gain further insight into this novel and unique provisional subtype.

摘要

浆细胞样树突状细胞（pDCs）是一种源自髓系的特定树突状细胞类型。临床上和病理学上，与 pDC 相关的肿瘤被分类为母细胞性浆细胞样树突细胞肿瘤（BPDCN）、成熟浆细胞样树突细胞髓系肿瘤（MPDMN）和髓系肿瘤中的 pDC 扩增（MNs）。BPDCN 在 2016 年世界卫生组织（WHO）分类中被认为是一种罕见且侵袭性的肿瘤。MPDMN，也称为成熟 pDC 衍生的肿瘤，与 MNs 密切相关，首次在最新的 2022 年 WHO 分类中被认识到，提出了一个新概念，即急性髓系白血病病例可能表现出克隆性扩增的 pDC（pDC-AML）。随着检测技术的进步，越来越多的 MN 中 pDC 扩增的报道，但发病机制是否与 MPDMN 相似尚不清楚。本综述重点关注 MN 中 pDC 扩增的患者特征、诊断和治疗，以更深入地了解这种新颖独特的暂定亚型。