通过临床发现预测百草枯中毒的死亡率，重点关注肺和心血管系统疾病。
Predicting mortality in paraquat poisoning through clinical findings, with a focus on pulmonary and cardiovascular system disorders.
作者信息
Tajai Preechaya, Kornjirakasemsan Akarawat
机构信息
Department of Forensic Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand.
Pharmacy Department, Nakornping Hospital, Chiang Mai, 50180, Thailand.
出版信息
J Pharm Policy Pract. 2023 Oct 20;16(1):123. doi: 10.1186/s40545-023-00635-z.
BACKGROUND
Paraquat, one of the most widely used herbicides, poses a significant risk of mortality through self-poisoning and subsequent multiple organ failure. The primary objective aimed to identify the factors associated with death in patients poisoned by paraquat.
METHODS
A cross-sectional retrospective review was conducted at a tertiary referral hospital over five years. Eligible patients presented with acute paraquat toxicity between 1 January 2016 and 31 December 2020. Medical records of 148 patients were reviewed.
RESULTS
The in-hospital fatality rate was found to be 21.8%. Multivariate analysis revealed that the amount of paraquat ingested and clinical presentations, particularly pulmonary and cardiovascular system disorders, were significantly associated with mortality.
CONCLUSION
Our study highlights that the amount of paraquat ingested, along with the presence of pulmonary and cardiovascular system disorders, can serve as prognostic indicators for mortality rates in cases of paraquat poisoning. These findings have important implications for physicians in predicting the prognosis and mortality of paraquat poisoning patients.
背景
百草枯是使用最广泛的除草剂之一，通过自我中毒及随后的多器官衰竭造成显著的死亡风险。主要目标旨在确定百草枯中毒患者死亡的相关因素。
方法
在一家三级转诊医院进行了为期五年的横断面回顾性研究。符合条件的患者在2016年1月1日至2020年12月31日期间出现急性百草枯中毒。对148例患者的病历进行了回顾。
结果
发现院内死亡率为21.8%。多因素分析显示，摄入百草枯的量和临床表现，尤其是肺部和心血管系统疾病，与死亡率显著相关。
结论
我们的研究强调，摄入百草枯的量以及肺部和心血管系统疾病的存在，可作为百草枯中毒病例死亡率的预后指标。这些发现对医生预测百草枯中毒患者的预后和死亡率具有重要意义。
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