Ge Jingwu, Zhang Chuanmeng, Peng Zhihang, Chu Minjuan, Chen Wensen, Li Zhanjie, Liu Shuangyuan, Yang Yongfeng, Chu Ming
Department of Infection Management, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210009, People's Republic of China.
The Center for Translational Medicine, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou, 225300, People's Republic of China.
Risk Manag Healthc Policy. 2023 Oct 17;16:2163-2170. doi: 10.2147/RMHP.S413639. eCollection 2023.
Patients infected with SARS-CoV-2 Delta VOC have a longer course of disease. We detected the air, surfaces, and patient's personal items in the wards of the second hospital of Nanjing during the outbreak of the COVID-19 Delta Variant to identify the environmental contamination, which provides a theoretical basis for the prevention and control of COVID-19 variation beads in the future.
In the cross-sectional study, we collected and analyzed clinical features, demographic and epidemiological data, laboratory and swab test results, and surface and air samples of 144 COVID-19 cases.
The time from symptom onset to surface sampling was 25 days (IQR, 21 to 33 days). Positive throat swabs were detected in 52(36.1%) patients, of which only 8(5.6%) patients had N or ORF1a/b genes Ct value <35 on the surface sampling day. Among the 692 environmental surface and air specimens collected from 144 COVID-19 cases, 3 specimens (3/692, 0.4%) related to 5 cases (3.5%, 5/144) were detected positive on RT-PCR. Overall, bedside tables (2/144, 1.4%) were most likely to be contaminated, followed by toilet seats (1/81, 1.2%).
The environmental contamination by SARS-CoV-2 Delta VOC-infected cases with disease duration of more than two weeks is limited.
感染严重急性呼吸综合征冠状病毒2（SARS-CoV-2）Delta变异株的患者病程较长。在新型冠状病毒肺炎（COVID-19）Delta变异株疫情期间，我们对南京医科大学第二附属医院病房内的空气、物体表面及患者个人物品进行检测，以明确环境污染情况，为今后COVID-19变异株的防控提供理论依据。
在这项横断面研究中，我们收集并分析了144例COVID-19病例的临床特征、人口统计学和流行病学数据、实验室及咽拭子检测结果以及物体表面和空气样本。
从症状出现到进行物体表面采样的时间为25天（四分位间距，21至33天）。52例（36.1%）患者咽拭子检测呈阳性，其中仅8例（5.6%）患者在物体表面采样当天N或ORF1a/b基因的Ct值<35。在从144例COVID-19病例中采集的692份环境物体表面和空气标本中，3份标本（3/692，0.4%）与5例患者（3.5%，5/144）相关，经逆转录聚合酶链反应（RT-PCR）检测呈阳性。总体而言，床头柜（2/144，1.4%）最容易被污染，其次是马桶座圈（1/81，1.2%）。
病程超过两周的SARS-CoV-2 Delta变异株感染病例造成的环境污染有限。
