卡比多巴左旋多巴对正常大鼠和帕金森病模型小鼠的镇痛作用。

Antinociceptive effects of carbidopa levodopa on normal rats and Parkinson's disease mice.

机构信息

School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation, Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, Shandong, China.

Department of Combine Traditional Chinese and Western Medicine, Yantai Yuhuangding Hospital Affiliated to Qingdao University Medical College, Yantai, Shandong, China.

出版信息

Pak J Pharm Sci. 2023 Sep;36(5):1489-1495.

PMID:37869925

Abstract

Carbidopa levodopa is widely used to ameliorate motor symptoms of Parkinson's disease (PD) patients. Pain is one of common symptoms of PD. The aim of this experiment is to study antinociceptive effects of carbidopa levodopa on normal rats and PD mice. Rats were intragastrically treated with carbidopa levodopa and the hind paw withdrawal latency (HWL) was investigated. PD mouse model was prepared with MPTP and then the antinociceptive effects of carbidopa levodopa on PD mice were evaluated. In normal rats, the HWL to thermal stimulus was augmented after carbidopa levodopa administration (p<0.05 or p<0.01) and carbidopa levodopa increased the HWL (p<0.05 or p<0.01) to mechanical stimulus. In PD mice, carbidopa levodopa elevated the HWL of the thermal stimulus in PD mice (p<0.05). Furthermore, the HWL in the inflammatory pain of PD mice was also increased by carbidopa levodopa treatmet (p<0.01). The current findings indicate that carbidopa levodopa has an antinociceptive effects in normal rats and PD mice. The analgesic effect of carbidopa levodopa on patients with or without PD is worth studying in further research.

摘要

卡比多巴左旋多巴被广泛用于改善帕金森病（PD）患者的运动症状。疼痛是 PD 的常见症状之一。本实验旨在研究卡比多巴左旋多巴对正常大鼠和 PD 小鼠的镇痛作用。大鼠给予卡比多巴左旋多巴灌胃，检测后爪退缩潜伏期（HWL）。用 MPTP 制备 PD 小鼠模型，然后评估卡比多巴左旋多巴对 PD 小鼠的镇痛作用。在正常大鼠中，卡比多巴左旋多巴给药后热刺激的 HWL 增加（p<0.05 或 p<0.01），并且卡比多巴左旋多巴增加了机械刺激的 HWL（p<0.05 或 p<0.01）。在 PD 小鼠中，卡比多巴左旋多巴升高了 PD 小鼠热刺激的 HWL（p<0.05）。此外，卡比多巴左旋多巴治疗还增加了 PD 小鼠炎症性疼痛的 HWL（p<0.01）。目前的研究结果表明，卡比多巴左旋多巴对正常大鼠和 PD 小鼠具有镇痛作用。卡比多巴左旋多巴对有或没有 PD 的患者的镇痛效果值得在进一步的研究中进行研究。