侵袭最恶劣模式对口腔鳞状细胞癌预后的影响：系统评价和荟萃分析。
Impact of worst pattern of invasion on prognosis of oral squamous cell carcinoma: a systematic review and meta-analysis.
机构信息
Department of Oral Diagnostic Sciences, King Abdulaziz University Faculty of Dentistry, Jeddah, Saudi Arabia.
Oral Maxillofacial Surgery and Oral Pathology Department, Faculty of Dentistry, University of Khartoum.
出版信息
J Int Med Res. 2023 Oct;51(10):3000605231206260. doi: 10.1177/03000605231206260.
OBJECTIVE
The relationship between the worst pattern of invasion (WPOI) and the prognosis of oral squamous cell carcinoma (OSCC) remains controversial. This systematic review and meta-analysis was performed to determine the impact of the WPOI on the prognosis of OSCC.
METHODS
Studies from six databases were assessed for quality using the Newcastle-Ottawa Scale, and data were analyzed using Stata software.
RESULTS
Eighteen studies involving 3954 patients showed that patients with a WPOI of 4 to 5 had significantly worse overall survival, disease-specific survival, and disease-free survival than patients with a WPOI of 1 to 3. Significant associations of the WPOI with locoregional recurrence and mortality were found.
CONCLUSION
A higher WPOI was significantly associated with a worse prognosis of OSCC across various outcomes. Incorporating the WPOI into standard histopathological assessments may guide personalized treatments and improve outcomes.
目的
侵袭最恶劣模式（WPOI）与口腔鳞状细胞癌（OSCC）预后之间的关系仍存在争议。本系统评价和荟萃分析旨在确定 WPOI 对 OSCC 预后的影响。
方法
使用纽卡斯尔-渥太华量表评估来自六个数据库的研究质量，并使用 Stata 软件进行数据分析。
结果
八项研究涉及 3954 名患者，结果表明 WPOI 为 4 至 5 的患者的总生存率、疾病特异性生存率和无病生存率明显低于 WPOI 为 1 至 3 的患者。WPOI 与局部区域复发和死亡率显著相关。
结论
较高的 WPOI 与各种结局的 OSCC 预后不良显著相关。将 WPOI 纳入标准组织病理学评估可能有助于指导个体化治疗并改善预后。
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