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在一个多样化的、与电子健康记录相关的洛杉矶生物样本库中，血清胆红素、吸烟与肺癌、头颈癌之间的相互作用

Interplay Of Serum Bilirubin and Tobacco Smoking with Lung and Head and Neck Cancers in a Diverse, EHR-linked Los Angeles Biobank.

作者信息

Venkateswaran Vidhya, Petter Ella, Boulier Kristin, Ding Yi, Bhattacharya Arjun, Pasaniuc Bogdan

机构信息

Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.

Department of Oral Biology, School of Dentistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.

出版信息

medRxiv. 2023 Oct 3:2023.09.29.23296364. doi: 10.1101/2023.09.29.23296364.

DOI:10.1101/2023.09.29.23296364

PMID:37873378

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10592991/

Abstract

BACKGROUND

Bilirubin is a potent antioxidant with a protective role in many diseases. We examined the relationships between serum bilirubin (SB) levels, tobacco smoking (a known cause of low SB), and aerodigestive cancers, grouped as lung (LC) and head and neck (HNC).

METHODS

We examined the associations between SB, LC and HNC using data from 393,210 participants from UCLA Health, employing regression models, propensity score matching, and polygenic scores.

RESULTS

Current tobacco smokers showed lower SB (-0.04mg/dL, 95% CI: [-0.04, -0.03]), compared to never-smokers. Lower SB levels were observed in HNC and LC cases (-0.10 mg/dL, [-0.13, -0.09] and -0.09 mg/dL, CI [-0.1, -0.07] respectively) compared to cancer-free controls with the effect persisting after adjusting for smoking. SB levels were inversely associated with HNC and LC risk (ORs per SD change in SB: 0.64, CI [0.59,0.69] and 0.57, CI [0.43,0.75], respectively). Lastly, a polygenic score (PGS) for SB was associated with LC (OR per SD change of SB-PGS: 0.71, CI [0.67, 0.76]).

CONCLUSIONS

Low SB levels are associated with an increased risk of both HNC and LC, independent of the effect of tobacco smoking with tobacco smoking demonstrating a strong interaction with SB on LC risk. Additionally, genetically predicted low SB (from polygenic scores) is negatively associated with LC.

IMPACT

These findings suggest that SB could serve as a potential early biomarker for LC and HNC.

摘要

背景

胆红素是一种强效抗氧化剂，在许多疾病中具有保护作用。我们研究了血清胆红素（SB）水平、吸烟（已知的低SB原因）与气消化道癌症之间的关系，气消化道癌症分为肺癌（LC）和头颈癌（HNC）。

方法

我们使用来自加州大学洛杉矶分校健康中心的393210名参与者的数据，采用回归模型、倾向得分匹配和多基因评分，研究了SB、LC和HNC之间的关联。

结果

与从不吸烟者相比，当前吸烟者的SB水平较低（-0.04mg/dL，95%CI：[-0.04，-0.03]）。与无癌对照相比，HNC和LC病例的SB水平较低（分别为-0.10mg/dL，[-0.13，-0.09]和-0.09mg/dL，CI[-0.1，-0.07]），在调整吸烟因素后，这种效应仍然存在。SB水平与HNC和LC风险呈负相关（SB每标准差变化的OR值：分别为0.64，CI[0.59，0.69]和0.57，CI[0.43，0.75]）。最后，SB的多基因评分（PGS）与LC相关（SB-PGS每标准差变化的OR值：0.71，CI[0.67，0.76]）。