Feng Jianyang, Lin Rongjin, Li Haoxian, Wang Jiayan, He Hong
Department of Obstetrics and Gynecology, Guangdong Provincial Key Laboratory of Major Obstetric Disease, the Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510000, China.
Department of Fetal Medicine and Prenatal Diagnosis, the Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510000, China.
Chin Med J (Engl). 2024 Feb 5;137(3):294-302. doi: 10.1097/CM9.0000000000002841. Epub 2023 Oct 24.
The disease burdens for endometrial cancer (EC) vary across different countries and geographical regions and change every year. Herein, we reported the updated results of the Global Burden of Disease Study 2019 on EC with respect to age-standardized incidence and mortality from 1990 to 2019.
The annual percentage change (APC) of incidence and mortality was evaluated using joinpoint regression analysis to examine the temporal trends during the same timeframe in terms of the global landscape, different sociodemographic indices (SDI), and geographic regions. The relationship between Human Development Index (HDI) and incidence and mortality was additionally explored.
The age-standardized incidence rates (ASIRs) revealed a significant average global elevation by 0.5% per year (95% confidence interval [CI], 0.3-0.7; P <0.001). The age-standardized mortality rates (ASMRs), in contrast, fell by an average of 0.8% per year (95% CI, -1.0 to -0.7; P <0.001) worldwide. The ASIRs and ASMRs for EC varied across different SDIs and geographical regions. We noted four temporal trends and a significant reduction by 0.5% per year since 2010 in the ASIR, whereas we detected six consecutively decreasing temporal trends in ASMR during the entire period. Notably, the estimated APCs were significantly positively correlated with HDIs (ρ = 0.22; 95% CI, 0.07-0.35; P = 0.003) with regard to incident cases in 2019.
Incidence rates for EC reflected a significant increase overall (although we observed a decline since 2010), and the death rates declined consecutively from 1990 to 2019. We posit that more precise strategies can be tailored and then implemented based on the distinct age-standardized incidence and mortality burden in different geographical areas.
子宫内膜癌（EC）的疾病负担在不同国家和地理区域有所不同，且每年都在变化。在此，我们报告了《2019年全球疾病负担研究》中关于1990年至2019年子宫内膜癌年龄标准化发病率和死亡率的最新结果。
使用Joinpoint回归分析评估发病率和死亡率的年度百分比变化（APC），以研究同一时间段内全球、不同社会人口学指数（SDI）和地理区域的时间趋势。此外，还探讨了人类发展指数（HDI）与发病率和死亡率之间的关系。
年龄标准化发病率（ASIR）显示全球平均每年显著上升0.5%（95%置信区间[CI]，0.3 - 0.7；P <0.001）。相比之下，全球年龄标准化死亡率（ASMR）平均每年下降0.8%（95% CI，-1.0至-0.7；P <0.001）。子宫内膜癌的ASIR和ASMR在不同的SDI和地理区域有所不同。我们注意到有四种时间趋势，自2010年以来ASIR每年显著下降0.5%，而在整个时期内我们检测到ASMR有六个连续下降的时间趋势。值得注意的是，就2019年的发病病例而言，估计的APC与HDI显著正相关（ρ = 0.22；95% CI，0.07 - 0.35；P = 0.003）。
子宫内膜癌的发病率总体上呈现显著上升（尽管我们观察到自2010年以来有所下降），并且死亡率从1990年到2019年连续下降。我们认为，可以根据不同地理区域独特的年龄标准化发病率和死亡率负担制定并实施更精确的策略。
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