Yamakuni Ryo, Sekino Hirofumi, Ikeda Masakazu, Endo Yoshiki, Ikeda Masamitsu, Ishii Shiro, Fukushima Kenji, Murono Shigeyuki, Suzuki Yoshiyuki, Ito Hiroshi
Department of Radiology and Nuclear Medicine, Fukushima Medical University School of Medicine, Fukushima, Japan.
Department of Otorhinolaryngology, Fukushima Medical University School of Medicine, Fukushima, Japan.
Radiol Case Rep. 2023 Oct 14;18(12):4514-4521. doi: 10.1016/j.radcr.2023.09.058. eCollection 2023 Dec.
Surgical resection is recommended for advanced-stage, resectable glottic cancer. However, total laryngectomy results in the loss of vocal function and reduces patients' quality of life. At our institution, patients with cT3N0M0 stage III resectable glottic cancer who wish to preserve their larynx are treated with super-selective cisplatin infusion with concomitant radiotherapy (RADPLAT) to improve local control over systemic chemotherapy. Herein, we present 4 patients with glottic cancer who underwent biweekly intra-arterial infusion chemotherapy combined with radiation therapy 3 times. For intra-arterial infusion chemotherapy, 100 mg cis-diaminodichloroplatinum was infused into the superior thyroid artery, including the superior laryngeal artery branch. Thereafter, intensity-modulated radiation therapy was administered at doses of 70 Gy in 35 fractions for 3 patients and 66 Gy in 33 fractions for 1 patient. These patients showed complete response after chemoradiotherapy with no recurrence or metastases during the follow-up period to date (mean follow-up period: 56 months, range: 39-76 months).
对于晚期可切除的声门癌，建议进行手术切除。然而，全喉切除术会导致发声功能丧失，降低患者的生活质量。在我们机构，对于希望保留喉部的cT3N0M0 III期可切除声门癌患者，采用超选择性顺铂灌注联合放疗（RADPLAT）进行治疗，以改善局部控制效果，优于全身化疗。在此，我们报告4例声门癌患者，他们接受了每两周一次的动脉内灌注化疗，并联合放疗3次。对于动脉内灌注化疗，将100 mg顺二氨基二氯铂注入甲状腺上动脉，包括喉上动脉分支。此后，3例患者接受了剂量为70 Gy、分35次的调强放疗，1例患者接受了剂量为66 Gy、分33次的调强放疗。这些患者在放化疗后显示完全缓解，截至目前的随访期内无复发或转移（平均随访期：56个月，范围：39 - 76个月）。
