Division of Infectious Diseases, School of Medicine, University of North Carolina, Chapel Hill, NC; Department of Infection Prevention, UNC Medical Center, Chapel Hill, NC.
Division of Infectious Diseases, School of Medicine, University of North Carolina, Chapel Hill, NC.
Am J Infect Control. 2023 Nov;51(11S):A114-A119. doi: 10.1016/j.ajic.2023.04.158.
Biofilms are surface-attached communities of bacteria embedded in an extracellular matrix. This matrix shields the resident cells from desiccation, chemical perturbation, invasion by other bacteria, and confers reduced susceptibility to antibiotics and disinfectants. There is growing evidence that biofilms on medical instruments (especially endoscopes) and environmental surfaces interfere with cleaning and disinfection.
The English literature on the impact of biofilms in medicine was reviewed with a focus on the impact of biofilms on reusable semicritical medical instruments and hospital environmental surfaces.
Biofilms are frequently present on hospital environmental surfaces and reusable medical equipment. Important health care...associated pathogens that readily form biofilms on environmental surfaces include Staphylococcus aureus, Pseudomonas aeruginosa, and Candida auris. Evidence has demonstrated that biofilms interfere with cleaning and disinfection.
New technologies such as ..úself-disinfecting..Ñ surfaces or continuous room disinfection systems may reduce or disrupt biofilm formation and are under study to reduce the impact of the contaminated surface environment on health care...associated infections.
Future research is urgently needed to develop methods to reduce or eliminate biofilms from forming on implantable medical devices, reusable medical equipment, and hospital surfaces.
生物膜是附着在表面的细菌群落，嵌入在细胞外基质中。这个基质保护着居住的细胞免受干燥、化学干扰、被其他细菌入侵，并降低了对抗生素和消毒剂的敏感性。越来越多的证据表明，医疗器械（尤其是内窥镜）和环境表面上的生物膜会干扰清洁和消毒。
我们对医学领域中生物膜的影响的英文文献进行了综述，重点关注生物膜对可重复使用的半关键医疗器械和医院环境表面的影响。
生物膜经常存在于医院环境表面和可重复使用的医疗器械上。容易在环境表面形成生物膜的重要医疗保健相关病原体包括金黄色葡萄球菌、铜绿假单胞菌和耳念珠菌。有证据表明，生物膜会干扰清洁和消毒。
新的技术，如自消毒表面或连续的房间消毒系统，可能会减少或破坏生物膜的形成，并正在研究中，以减少受污染的表面环境对医疗保健相关感染的影响。
迫切需要未来的研究来开发方法，以减少或消除可植入医疗器械、可重复使用的医疗器械和医院表面上生物膜的形成。
