Yunnan Key Laboratory of Stem Cell and Regenerative Medicine, Science and Technology Achievement Incubation Center, NHC Key Laboratory of Drug Addiction Medicine, Kunming Medical University, 1168 West Chunrong Road, Yuhua Avenue, Chenggong District, Kunming, 650500, Yunnan, China.
Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Kunming Medical University, Kunming, 650106, Yunnan, China.
Mol Diagn Ther. 2024 Jan;28(1):53-67. doi: 10.1007/s40291-023-00681-y. Epub 2023 Oct 28.
MicroRNAs (miRNAs) are endogenous noncoding RNAs that mediate the fibrotic process by regulating multiple targets. MicroRNA-based therapy can restore or inhibit miRNA expression and is expected to become an effective approach to prevent and alleviate fibrotic diseases. However, the safe, targeted, and effective delivery of miRNAs is a major challenge in translating miRNA therapy from bench to bedside. In this review, we briefly describe the pathophysiological process of fibrosis and the mechanism by which miRNAs regulate the progression of fibrosis. Additionally, we summarize the miRNA nanodelivery tools for fibrotic diseases, including chemical modifications and polymer-based, lipid-based, and exosome-based delivery systems. Further clarification of the role of miRNAs in fibrosis and the development of a novel nanodelivery system may facilitate the prevention and alleviation of fibrotic diseases in the future.
微小 RNA（miRNA）是内源性非编码 RNA，通过调节多个靶标来介导纤维化过程。基于 miRNA 的治疗可以恢复或抑制 miRNA 的表达，有望成为预防和减轻纤维化疾病的有效方法。然而，miRNA 的安全、靶向和有效传递是将 miRNA 治疗从实验室转化到临床的主要挑战。在这篇综述中，我们简要描述了纤维化的病理生理过程以及 miRNA 调节纤维化进展的机制。此外，我们总结了用于纤维化疾病的 miRNA 纳米递药工具，包括化学修饰以及基于聚合物、基于脂质和基于外泌体的递药系统。进一步阐明 miRNA 在纤维化中的作用以及开发新型纳米递药系统可能有助于未来预防和减轻纤维化疾病。
Mol Diagn Ther. 2024-1
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