Liaoning University of Traditional Chinese Medicine, Shenyang, China.
Department of Breast Surgery, Cancer Hospital of Dalian University of Technology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, Shenyang, China.
Medicine (Baltimore). 2023 Oct 27;102(43):e35493. doi: 10.1097/MD.0000000000035493.
Triple-negative breast cancer (TNBC) is a subtype of breast cancer (BC) that is highly aggressive and hypoxic compared with other subtypes. The role of hypoxia-inducible factor 1α (HIF-1α) as a key hypoxic transcription factor in oncogenic processes has been extensively studied. Recently, it has been shown that HIF-1α regulates the complex biological processes of TNBC, such as glycolysis, angiogenesis, invasion and metastasis, BC stem cells enrichment, and immune escape, to promote TNBC survival and development through the activation of downstream target genes. This article discusses the expression of the HIF-1α transcription factor in TNBC and the Hypoxia-mediated activation of hypoxia-inducible factor-1α in triple-negative BC. It offers a fresh approach to clinical research and treatment for TNBC.
三阴性乳腺癌（TNBC）是一种侵袭性较强且缺氧的乳腺癌（BC）亚型，与其他亚型相比。缺氧诱导因子 1α（HIF-1α）作为一种关键的缺氧转录因子在致癌过程中的作用已被广泛研究。最近，研究表明 HIF-1α 通过激活下游靶基因，调节 TNBC 的复杂生物学过程，如糖酵解、血管生成、侵袭和转移、BC 干细胞富集和免疫逃逸，从而促进 TNBC 的存活和发展。本文讨论了 HIF-1α 转录因子在 TNBC 中的表达以及缺氧诱导因子-1α在三阴性 BC 中的缺氧介导激活，为 TNBC 的临床研究和治疗提供了新的思路。
