带状疱疹病毒感染与痴呆发生风险：系统评价和荟萃分析。

Herpes Zoster virus infection and the risk of developing dementia: A systematic review and meta-analysis.

机构信息

Faculty of Medicine, Alexandria University, Alexandria, Egypt.

Weill Cornell Medicine, New York, NY, USA.

出版信息

Medicine (Baltimore). 2023 Oct 27;102(43):e34503. doi: 10.1097/MD.0000000000034503.

DOI:10.1097/MD.0000000000034503

PMID:37904465

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10615483/

Abstract

BACKGROUND

Herpes Zoster, commonly known as shingles, is a viral infection that affects a significant portion of the adult population; however, its potential role in the onset or progression of neurodegenerative disorders like dementia remains unclear.

METHODS

We searched the following databases: PubMed, Scopus, Cochrane library, and Web of Science. We included any randomized control trials and controlled observational studies as Cross-sectional, prospective, or retrospective cohort and case-control studies that investigated the prevalence of dementia in Herpes Zoster Virus (HZV)-infected patients and HZV-free control group or if the study investigated the prevalence of HZV in demented patients. Also, if the studies measured the levels of dementia biomarkers in patients with HZV compared with a healthy control group.

RESULTS

After the complete screening, 9 studies were included in the meta-analysis. In the outcome of the incidence of HZV, the pooled analysis showed no statistically significant difference between the dementia group and the No dementia group (RR = 1.04% CI = 0.86-1.25, P = .70). In the outcome of incidences of dementia and Alzheimer's disease, the pooled analysis showed no statistically significant difference between the HZV group and the incidence of dementia (RR = 0.99, 95% CI = 0.92-1.08, P = .89), (RR = 3.74, 95% CI = 0.22-62.70, P = .36) respectively. In the outcome of incidences of Herpes Zoster ophthalmicus (HZO), the generic inverse variance showed a statistically significant association between patients who have HZO and increased incidence of dementia (RR = 6.26, 95% CI = 1.30-30.19, P = .02).

CONCLUSION

Our study showed no significant association between HZV and the incidence of dementia or Alzheimer's disease, but it shows a significant association between HZO and the incidence of dementia. More multicenter studies are needed to establish the actual association between the HZV and dementia.

摘要

背景

带状疱疹，俗称带状疱疹，是一种影响很大一部分成年人的病毒感染；然而，它在痴呆等神经退行性疾病的发病或进展中的潜在作用尚不清楚。

方法

我们搜索了以下数据库：PubMed、Scopus、Cochrane 图书馆和 Web of Science。我们纳入了任何随机对照试验和对照观察性研究，包括横断面、前瞻性或回顾性队列和病例对照研究，这些研究调查了带状疱疹病毒（HZV）感染患者和 HZV 无对照组中痴呆的患病率，或者研究调查了痴呆患者中 HZV 的患病率。此外，如果研究测量了 HZV 患者与健康对照组相比的痴呆生物标志物水平。

结果

经过全面筛选，有 9 项研究纳入荟萃分析。在 HZV 发病率的结果中，汇总分析显示痴呆组与非痴呆组之间无统计学显著差异（RR=1.04%CI=0.86-1.25，P=0.70）。在痴呆和阿尔茨海默病发病率的结果中，汇总分析显示 HZV 组与痴呆发病率之间无统计学显著差异（RR=0.99，95%CI=0.92-1.08，P=0.89），（RR=3.74，95%CI=0.22-62.70，P=0.36）。在 HZO 发病率的结果中，通用逆方差显示患有 HZO 的患者与痴呆发病率增加之间存在统计学显著关联（RR=6.26，95%CI=1.30-30.19，P=0.02）。