Department of Biochemistry and Molecular Biology, Mawlana Bhashani Science and Technology University, Tangail, Bangladesh.
Department of Medicine, Chittagong Medical College Hospital, Chattogram, Bangladesh.
J Clin Lab Anal. 2023 Nov;37(21-22):e24980. doi: 10.1002/jcla.24980. Epub 2023 Oct 31.
Organophosphorus compound (OPC) poisoning undoubtedly being a major concern in cultivation sites of the developing world, including Bangladesh. Two potential biomarkers, for example, serum creatine phosphokinase (CPK) and lactate dehydrogenase (LDH), are widely used in OPC poisoning severity indicators in patients. In this study, we sought to correlate the severity score of acute OPC poisoning with CPK or LDH level and subsequently explore their prognostic value.
This study was performed on a total of 70 patients with OPC poisoning admitted to the inpatient care unit at a territory-based hospital in Bangladesh. Sociodemographics and poison types were recorded, and severity was assessed according to Peradeniya Organophosphorus Poisoning (POP) scale. Serum CPK and LDH levels were measured and recorded.
A total of seventy OPC patients were included with male to female ratio of 1.33:1, respectively, with a mean age of 28.7 ± 12.8 years. Chlorpyrifos and methylparathion were the most commonly utilized OP compounds, accounting for 42.9% and 28.6%, respectively. Among the OPC patients, the majority were married homemakers from rural areas. According to POP score, 55.7% and 37.1% of patients were categorized as mild and moderate, whereas very few were found to be severe. The mean serum CPK and LDH of OPC-patients at admission time were 235.6 ± 79.8 IU/L and 348.3 ± 154.1 IU/L, respectively. Serum CPK, atropine dose and hospital stay strongly correlated with clinical severity.
We conclude that the serum CPK level strongly correlates with the degree of OPC poisoning and can be used as a predictor of the clinical intervention approaches.
有机磷化合物 (OPC) 中毒无疑是发展中国家包括孟加拉国种植区的主要关注点。两种潜在的生物标志物，例如血清肌酸磷酸激酶（CPK）和乳酸脱氢酶（LDH），广泛用于患者 OPC 中毒严重程度的指标。在这项研究中，我们试图将急性 OPC 中毒的严重程度评分与 CPK 或 LDH 水平相关联，并随后探讨其预后价值。
这项研究共纳入了 70 名在孟加拉国一家基于地区的医院住院部就诊的 OPC 中毒患者。记录了社会人口统计学和毒物类型，并根据佩拉德尼亚有机磷中毒（POP）量表评估严重程度。测量并记录血清 CPK 和 LDH 水平。
共纳入 70 名 OPC 患者，男女比例为 1.33:1，平均年龄为 28.7±12.8 岁。毒死蜱和甲基对硫磷是最常用的 OP 化合物，分别占 42.9%和 28.6%。在 OPC 患者中，大多数是已婚的农村家庭主妇。根据 POP 评分，55.7%和 37.1%的患者被归类为轻度和中度，而很少有患者被归类为重度。OPC 患者入院时的血清 CPK 和 LDH 均值分别为 235.6±79.8 IU/L 和 348.3±154.1 IU/L。血清 CPK、阿托品剂量和住院时间与临床严重程度密切相关。
我们的结论是，血清 CPK 水平与 OPC 中毒的严重程度密切相关，可作为临床干预方法的预测指标。
