多发性硬化症患者的合并自身免疫性疾病：一项回顾性队列研究。

Comorbid autoimmune disorders in people with multiple sclerosis: A retrospective cohort study.

作者信息

Leal Rato Miguel, Santos Mónica, de Sá João, Ferreira João

机构信息

Serviço de Neurologia, Departamento de Neurociências e Saúde Mental, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte, Lisboa, Portugal; Instituto de Farmacologia e Neurociências, Faculdade de Medicina da Universidade de Lisboa, Lisboa, Portugal.

Serviço de Neurologia, Departamento de Neurociências e Saúde Mental, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte, Lisboa, Portugal.

出版信息

J Neuroimmunol. 2023 Dec 15;385:578226. doi: 10.1016/j.jneuroim.2023.578226. Epub 2023 Oct 29.

DOI:10.1016/j.jneuroim.2023.578226

PMID:37918214

Abstract

Most autoimmune disorders, including multiple sclerosis (MS), are influenced by shared genetic and environmental factors. We conducted a cohort study of people with MS to calculate the frequency of comorbid autoimmune disorders and characterize this cohort. Autoimmune diseases were present in 30 (8.6%) of 349 patients. The most prevalent diagnoses were autoimmune thyroiditis, type 1 diabetes mellitus, psoriasis, and inflammatory bowel disease. We found no association with demographic or clinical factors. In our cohort, autoimmune disorders were not uncommon. Identifying such comorbidities in people with MS can be determinant for understanding disease mechanisms, treatment decisions and disease management.

摘要

大多数自身免疫性疾病，包括多发性硬化症（MS），都受到共同的遗传和环境因素影响。我们对多发性硬化症患者进行了一项队列研究，以计算合并自身免疫性疾病的频率并描述该队列的特征。349例患者中有30例（8.6%）患有自身免疫性疾病。最常见的诊断是自身免疫性甲状腺炎、1型糖尿病、银屑病和炎症性肠病。我们未发现其与人口统计学或临床因素有关联。在我们的队列中，自身免疫性疾病并不罕见。在多发性硬化症患者中识别此类合并症对于理解疾病机制、治疗决策和疾病管理可能具有决定性意义。