Chitkara College of Pharmacy, Chitkara University, Rajpura, 140401, Punjab, India.
Department of Pharmacy, Institute of Pharmaceutical Research, GLA University, U.P., India.
Curr Med Chem. 2024;31(41):6855-6870. doi: 10.2174/0109298673250784231011094322.
Neurological disorders are possibly the most prevalent and have been identified to occur among individuals with autism beyond chance. These disorders encompass a diverse range of consequences with neurological causes and have been regarded as a major threat to public mental health. There is no tried-and-true approach for completely protecting the nervous system. Therefore, plant-derived compounds have developed significantly nowadays. Coumestrol (CML) is a potent isoflavone phytoestrogen with a protective effect against neurological dysfunction and has been discovered to be structurally and functionally similar to estrogen. In recent years, more research has been undertaken on phytoestrogens. This research demonstrates the biological complexity of phytoestrogens, which consist of multiple chemical families and function in various ways. This review aimed to explore recent findings on the most significant pharmacological advantages of CML by emphasising neurological benefits. Numerous CML extraction strategies and their pharmacological effects on various neurological disorders, including PD, AD, HD, anxiety, and cognitive impairments, were also documented.
神经紊乱可能是最常见的，并且已经被确定在自闭症患者中发生的几率超出偶然。这些紊乱包含了具有神经病因的多种后果，并被认为是对公众心理健康的主要威胁。目前还没有经过验证的方法可以完全保护神经系统。因此，如今植物衍生的化合物已经有了显著的发展。香豆雌酚（CML）是一种有效的异黄酮植物雌激素，对神经功能障碍有保护作用，并且被发现其结构和功能与雌激素相似。近年来，对植物雌激素的研究越来越多。这项研究表明了植物雌激素的生物学复杂性，它由多个化学家族组成，以多种方式发挥作用。本综述旨在通过强调神经益处，探讨 CML 最重要的药理学优势的最新发现。还记录了许多 CML 提取策略及其对各种神经紊乱的药理作用，包括 PD、AD、HD、焦虑和认知障碍。
