维甲酸治疗疣状表皮发育不良失败。
Failure of etretinate in epidermodysplasia verruciformis.
作者信息
Kowalzick L, Mensing H
出版信息
Dermatologica. 1986;173(2):75-8. doi: 10.1159/000249222.
PMID:3792602
Abstract
In a patient suffering from benign lesions of epidermodysplasia verruciformis due to human papillomavirus type 5 little clinical improvement could be observed after 6 months of oral etretinate. The drug was given 75 mg/day for 1 month before dosage was reduced to 50 mg/day. Control biopsy after 3 months of treatment still revealed large quantities of virions and typical cytopathic effects in light and electron microscopic examination.
摘要
对于一名因5型人乳头瘤病毒导致疣状表皮发育不良良性病变的患者，口服依曲替酯6个月后未观察到明显临床改善。给药时先以每日75毫克的剂量服用1个月，之后减至每日50毫克。治疗3个月后的对照活检在光镜和电镜检查中仍显示有大量病毒颗粒及典型的细胞病变效应。
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