Caimmi Davide, Clark Evangéline, Fogel Paul, Heddebaut Nicolas, Aubier Michel, Demoly Pascal
Department Respiratory Medicine and Allergy, Allergy Unit, Hôpital Arnaud de Villeneuve, University Hospital of Montpellier, Montpellier, France.
Université de Montpellier, DESP, INSERM, Montpellier, France.
Int Arch Allergy Immunol. 2024;185(2):111-115. doi: 10.1159/000533271. Epub 2023 Nov 3.
Patients suffering from allergic rhinitis seek for several therapeutic symptomatic options, including nonconventional treatments, to control their symptoms.
Through the present proof-of-concept study, we prospectively investigated the potential role of Puressentiel® nasal protection spray (SNPA) in patients suffering from cypress pollen allergic rhinitis.
In 15 adults, we performed two nasal provocation tests, with a cypress pollen extract, with a 15-day interval, with and without previous randomized administration of SNPA, and evaluated a nasal symptom score, the nasal inspiratory peak flow, and the concentration of inflammatory cytokines in the nasal lavage after the procedures.
Comparing results in patients challenged with and without the SNPA spray before the nasal challenge, we found a 57% mean decrease in symptoms, and a 62% average difference in inspiratory peak flow, after the use of the spray.
Puressentiel® SNPA is effective in reducing nasal symptoms, as assessed by nasal symptoms score and nasal inspiratory peak flow, and could be a valid natural non-pharmacological option in patients suffering from allergic rhinitis.
过敏性鼻炎患者寻求多种治疗症状的选择，包括非常规治疗，以控制其症状。
通过本概念验证研究，我们前瞻性地研究了普瑞森泰尔®鼻腔保护喷雾（SNPA）在柏树花粉过敏性鼻炎患者中的潜在作用。
在15名成年人中，我们进行了两次鼻腔激发试验，间隔15天，使用柏树花粉提取物，一次在随机使用SNPA之前，一次在之后，并在试验后评估鼻腔症状评分、鼻腔吸气峰流速以及鼻腔灌洗中炎症细胞因子的浓度。
比较鼻腔激发试验前使用和未使用SNPA喷雾的患者的结果，我们发现使用喷雾后症状平均减轻57%，吸气峰流速平均差异为62%。
根据鼻腔症状评分和鼻腔吸气峰流速评估，普瑞森泰尔®SNPA在减轻鼻腔症状方面有效，并且可能是过敏性鼻炎患者有效的天然非药物选择。
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