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瑞士环境下预测关节镜下肩袖修复术后患者报告的肩部功能的模型的开发与内部验证

Development and internal validation of a model predicting patient-reported shoulder function after arthroscopic rotator cuff repair in a Swiss setting.

作者信息

Stojanov Thomas, Aghlmandi Soheila, Müller Andreas Marc, Scheibel Markus, Flury Matthias, Audigé Laurent

机构信息

Department of Orthopaedic Surgery and Traumatology, University Hospital of Basel, Basel, Switzerland.

Research and Development, Shoulder and Elbow Surgery, Schulthess Clinic, Zurich, Switzerland.

出版信息

Diagn Progn Res. 2023 Nov 7;7(1):21. doi: 10.1186/s41512-023-00156-y.

Abstract

BACKGROUND

Prediction models for outcomes after orthopedic surgery provide patients with evidence-based postoperative outcome expectations. Our objectives were (1) to identify prognostic factors associated with the postoperative shoulder function outcome (the Oxford Shoulder Score (OSS)) and (2) to develop and validate a prediction model for postoperative OSS.

METHODS

Patients undergoing arthroscopic rotator cuff repair (ARCR) were prospectively documented at a Swiss orthopedic tertiary care center. The first primary ARCR in adult patients with a partial or complete rotator cuff tear were included between October 2013 and June 2021. Thirty-two potential prognostic factors were used for prediction model development. Two sets of factors identified using the knowledge from three experienced surgeons (Set 1) and Bayesian projection predictive variable selection (Set 2) were compared in terms of model performance using R squared and root-mean-squared error (RMSE) across 45 multiple imputed data sets using chained equations and complete case data.

RESULTS

Multiple imputation using data from 1510 patients was performed. Set 2 retained the following factors: American Society of Anesthesiologists (ASA) classification, baseline level of depression and anxiety, baseline OSS, operation duration, tear severity, and biceps status and treatment. Apparent model performance was R-squared = 0.174 and RMSE = 7.514, dropping to R-squared = 0.156, and RMSE = 7.603 after correction for optimism.

CONCLUSION

A prediction model for patients undergoing ARCR was developed using solely baseline and operative data in order to provide patients and surgeons with individualized expectations for postoperative shoulder function outcomes. Yet, model performance should be improved before being used in clinical routine.

摘要

背景

骨科手术后结果的预测模型为患者提供基于证据的术后结果预期。我们的目标是:(1)识别与术后肩部功能结果(牛津肩部评分(OSS))相关的预后因素;(2)开发并验证术后OSS的预测模型。

方法

在瑞士一家骨科三级护理中心对接受关节镜下肩袖修补术(ARCR)的患者进行前瞻性记录。纳入2013年10月至2021年6月期间首次接受成人部分或完全肩袖撕裂的初次ARCR患者。使用32个潜在的预后因素进行预测模型开发。使用链式方程和完整病例数据,在45个多重插补数据集上,根据决定系数(R平方)和均方根误差(RMSE),比较了使用三位经验丰富的外科医生的知识确定的两组因素(第1组)和贝叶斯投影预测变量选择(第2组)在模型性能方面的差异。

结果

对1510例患者的数据进行了多重插补。第2组保留了以下因素:美国麻醉医师协会(ASA)分级、抑郁和焦虑的基线水平、基线OSS、手术持续时间、撕裂严重程度以及肱二头肌状态和治疗情况。表观模型性能为R平方 = 0.174,RMSE = 7.514,校正乐观偏差后降至R平方 = 0.156,RMSE = 7.603。

结论

仅使用基线和手术数据为接受ARCR的患者开发了一个预测模型,以便为患者和外科医生提供术后肩部功能结果的个性化预期。然而,在临床常规应用之前,模型性能仍需改进。

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