Department of Social Medicine, National Center for Child Health and Development, Tokyo, Japan.
Department of Pediatrics, Faculty of Medicine, Juntendo University, Tokyo, Japan.
Sci Rep. 2023 Nov 10;13(1):19612. doi: 10.1038/s41598-023-45316-8.
To examine whether the prevailing hypothesis of an association between caesarean section (CS) delivery method and increased weight status in early childhood is observed in Japanese. A total of 1277 mother-infant pairs from a prospective hospital-based mother-infant birth cohort that recruited women in their first trimester from May 2010 to November 2013 were included. We assessed the relationship between delivery method and weight status of delivered children at 1, 3 and 6 years of age. In total, 366 children (28.7%) were delivered by CS. Delivery by CS was not associated with body mass index (BMI) z-score (≥ 75 percentile) at age 1 year, (odds ratio (OR) 0.97, 95% confidence interval (CI) 0.69-1.36), 3 years (OR 0.98, 95% CI 0.67-1.42), and 6 years (OR 0.71, 95% CI 0.45-1.12), and also showed no association with low weight status (< 25th percentile). Supplemental evaluations addressing the influence of preterm births, pre-pregnancy BMI, emergency CS, and modification by breastfeeding were consistent with the primary analyses. Our findings do not support the hypothesis that children born by CS are at risk of being overweight in childhood among the Japanese population.
为了检验在日本人群中，剖宫产分娩方式与儿童早期超重之间的关联这一主流假说是否成立。我们共纳入了 1277 对母婴，来自一个前瞻性的基于医院的母婴出生队列，该队列于 2010 年 5 月至 2013 年 11 月招募了处于孕早期的女性。我们评估了分娩方式与分娩后儿童在 1、3 和 6 岁时的体重状况之间的关系。共有 366 名儿童（28.7%）经剖宫产分娩。剖宫产分娩与 1 岁时的体重指数（BMI）Z 评分（≥75 百分位数）无关（比值比（OR）0.97，95%置信区间（CI）0.69-1.36）、3 岁（OR 0.98，95% CI 0.67-1.42）和 6 岁（OR 0.71，95% CI 0.45-1.12），也与低体重状况（<25 百分位数）无关。对早产、孕前 BMI、急诊剖宫产以及母乳喂养调整的补充评估结果与主要分析一致。我们的研究结果并不支持剖宫产分娩的儿童在日本人群中存在儿童期超重风险的假说。
