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芬太尼与昂丹司琼预防剖宫产术中寒战的比较研究

Fentanyl Versus Ondansetron for Shivering Prevention in Cesarean Section: A Comparative Study.

作者信息

Hasan Shaimaa H, Haji Qadir Reabar, Mohammed Haider N

机构信息

Anesthesia Department, College of Health Sciences, University of Duhok, Duhok, IRQ.

出版信息

Cureus. 2023 Oct 10;15(10):e46817. doi: 10.7759/cureus.46817. eCollection 2023 Oct.

Abstract

BACKGROUND AND PURPOSE

The incidence of postoperative shivering (PS) following intrathecal anesthesia is a common complication, with potential negative impacts on patient outcomes. This study aims to evaluate the effectiveness of intrathecal fentanyl versus intravenous ondansetron in preventing post-spinal anesthesia shivering in cesarean section patients.

EXPERIMENTAL APPROACH

A randomized controlled trial was conducted from July 2021 to April 2023, involving pregnant women scheduled for cesarean section under intrathecal anesthesia. The participants were divided into three groups: group F received intrathecal fentanyl (15 μg) with spinal anesthesia, while group O received intravenous ondansetron (8 mg) added to the usual saline solution. The control group (group C) received only intravenous fluid before spinal anesthesia and intrathecal bupivacaine without fentanyl. Shivering occurrences were observed and recorded during the procedure.

KEY RESULTS

The incidence of shivering was significantly lower in the fentanyl and ondansetron groups compared to the control group (p=0.0123). Both intrathecal fentanyl and intravenous ondansetron administration showed effectiveness in reducing shivering during spinal anesthesia.

CONCLUSION

The administration of intrathecal fentanyl and intravenous ondansetron significantly reduced the occurrence of shivering during spinal anesthesia in cesarean section patients. This study contributes to advancing knowledge in the field by providing evidence of the preventative effects of these medications on post-spinal anesthesia shivering.

摘要

背景与目的

鞘内麻醉后术后寒战(PS)的发生率是一种常见并发症,对患者预后有潜在负面影响。本研究旨在评估鞘内注射芬太尼与静脉注射昂丹司琼在预防剖宫产患者脊髓麻醉后寒战方面的有效性。

实验方法

于2021年7月至2023年4月进行了一项随机对照试验,纳入计划接受鞘内麻醉剖宫产的孕妇。参与者分为三组:F组在脊髓麻醉时接受鞘内注射芬太尼(15μg),而O组在常规盐溶液中加入静脉注射昂丹司琼(8mg)。对照组(C组)在脊髓麻醉前仅接受静脉输液,并接受不含芬太尼的鞘内布比卡因。在手术过程中观察并记录寒战的发生情况。

主要结果

与对照组相比,芬太尼组和昂丹司琼组的寒战发生率显著更低(p = 0.0123)。鞘内注射芬太尼和静脉注射昂丹司琼在减少脊髓麻醉期间的寒战方面均显示出有效性。

结论

鞘内注射芬太尼和静脉注射昂丹司琼显著降低了剖宫产患者脊髓麻醉期间寒战的发生率。本研究通过提供这些药物对脊髓麻醉后寒战预防作用的证据,为该领域的知识进步做出了贡献。

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