Obstetrics Department, Kunming Medical University Second Affiliated Hospital, Kunming, Yunnan, China.
Biol Reprod. 2024 Feb 10;110(2):220-229. doi: 10.1093/biolre/ioad157.
Recurrent spontaneous abortion (RSA) has various causes, including chromosomal abnormalities, prethrombotic state, and abnormal uterine anatomical factors. However, the pathogenesis of RSA is still unclear. Surprisingly, non-coding RNA can stably express at the maternal-fetal interface and regulate immune cells' proliferation, apoptosis, invasion, metastasis, and angiogenesis. Accumulating evidence suggests that the competing endogenous RNA (ceRNA) regulatory network between non-coding RNAs complicates RSA's pathological process and maybe a new starting point for exploring RSA. In this review, we mainly discuss the regulatory network and potential significance of non-coding RNA in the immune microenvironment of RSA patients. In addition, the cellular interactions of non-coding RNA transported through vesicles were introduced from aspects of trophoblast function and immune regulation. Finally, we analyze previous studies and further discuss that the stable expression of non-coding RNA may be used as a biomarker of some disease states and a prediction target of RSA.
复发性自然流产（RSA）的病因多种多样，包括染色体异常、血栓前状态和子宫解剖学异常等。然而，RSA 的发病机制仍不清楚。令人惊讶的是，非编码 RNA 可以在母胎界面稳定表达，并调节免疫细胞的增殖、凋亡、侵袭、转移和血管生成。越来越多的证据表明，非编码 RNA 之间的竞争内源性 RNA（ceRNA）调控网络使 RSA 的病理过程复杂化，可能成为探索 RSA 的新起点。在这篇综述中，我们主要讨论了非编码 RNA 在 RSA 患者免疫微环境中的调控网络及其潜在意义。此外，还从滋养细胞功能和免疫调节方面介绍了通过囊泡运输的非编码 RNA 的细胞相互作用。最后，我们分析了之前的研究，并进一步讨论了非编码 RNA 的稳定表达可能被用作某些疾病状态的生物标志物和 RSA 的预测靶点。
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