Zambri Matthew T, Ho Celine, Taylor Mark S
Department of Chemistry, University of Toronto, 80 St. George St., Toronto, Ontario M5S 3H6, Canada.
Org Lett. 2023 Nov 24;25(46):8274-8278. doi: 10.1021/acs.orglett.3c03323. Epub 2023 Nov 14.
Synergistic organoboron/palladium cocatalysis enables dehydrative couplings of H-sulfoximines with allylic alcohols, furnishing the corresponding -allylated products. The reactions proceed in the absence of a Brønsted base and are tolerant of diverse sulfoximine partners, including functionalized variants. Experimental and computational studies suggest that the sulfoximine reagent is activated by complexation to the boronic acid cocatalyst.
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