Du Haoliang, Chen Jie, Qian Xiaoyun, Ding Xiaoqiong, Zhang Jian, Liu Bin, Yu Chenjie, Li Ao, Gao Xia, Feng Xu
Department of Otolaryngology and Head-and-Neck Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China,
Department of Research Institution of Otolaryngology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China,
Audiol Neurootol. 2024;29(2):146-166. doi: 10.1159/000534659. Epub 2023 Nov 14.
INTRODUCTION: The aim of the study was to investigate differences in the intra- and inter-network functional connectivity (FC) of the brain using resting-state functional magnetic resonance imaging (rs-fMRI) in patients with tinnitus, with (T + H) or without hearing loss (T). METHODS: We performed rs-fMRI on 82 participants (21 T, 32 T + H, and 29 healthy controls). An independent component analysis (ICA) was performed to obtain the resting-state networks (RSNs) and calculate the differences in FC. Moreover, we investigated the relationships between networks using functional network connectivity analysis. RESULTS: We identified nine major RSNs, including the auditory network; default mode network; executive control network (ECN), including the right frontoparietal network and left frontoparietal network (LFPN); somatomotor network (SMN); dorsal attention network; ventral attention network; salience network (SN); and visual network (VN). These RSNs were extracted in all groups using ICA. Compared with that in the control group, we observed reduced FC between the LFPN and VN in the T group and between the LFPN and SN in the T + H group. The inter-network connectivity analysis revealed decreased network interactions in the SMN (IC 22)-ECN (IC 2), SMN (IC 22)-VN (IC 8), and VN (IC 14)-SN (IC 3) connections in the T + H group, compared with the healthy control group. Furthermore, we observed significantly decreased network interactions in the SMN (IC 22)-VN (IC 8) in the T group. CONCLUSIONS: Our results indicated abnormalities within the brain networks of the T and T + H groups, including the SMN, ECN, and VN, compared with the control group. Furthermore, both T and T + H groups demonstrated reduced FC between the LFPN, VN, and SMN. There were no significant differences between the T and the T + H groups. Furthermore, we observed reduced FC between the right olfactory cortex and the orbital part of the right middle frontal gyrus, right precentral gyrus, left dorsolateral superior frontal gyrus, and right triangular part of the inferior frontal gyrus within the T and T + H groups. Thus, disruptions in brain regions responsible for attention, stimulus monitoring, and auditory orientation contribute to tinnitus generation.
引言：本研究旨在利用静息态功能磁共振成像（rs-fMRI），调查耳鸣患者（伴有听力损失的耳鸣患者（T + H）或不伴有听力损失的耳鸣患者（T））大脑内部和网络间功能连接（FC）的差异。 方法：我们对82名参与者（21名T组患者、32名T + H组患者和29名健康对照者）进行了rs-fMRI检查。进行独立成分分析（ICA）以获得静息态网络（RSN）并计算FC差异。此外，我们使用功能网络连接分析研究了各网络之间的关系。 结果：我们识别出九个主要的RSN，包括听觉网络、默认模式网络、执行控制网络（ECN），其中ECN包括右侧额顶叶网络和左侧额顶叶网络（LFPN）、躯体运动网络（SMN）、背侧注意网络、腹侧注意网络、突显网络（SN）和视觉网络（VN）。使用ICA在所有组中提取了这些RSN。与对照组相比，我们观察到T组中LFPN与VN之间以及T + H组中LFPN与SN之间的FC降低。网络间连接性分析显示，与健康对照组相比，T + H组中SMN（IC 22）-ECN（IC 2）、SMN（IC 22）-VN（IC 8）和VN（IC 14）-SN（IC 3）连接中的网络相互作用减少。此外，我们观察到T组中SMN（IC 22）-VN（IC 8）的网络相互作用显著减少。 结论：我们的结果表明，与对照组相比，T组和T + H组的脑网络存在异常，包括SMN、ECN和VN。此外，T组和T + H组在LFPN、VN和SMN之间均表现出FC降低。T组和T + H组之间无显著差异。此外，我们观察到T组和T + H组中右侧嗅觉皮层与右侧额中回眶部、右侧中央前回、左侧背外侧额上回以及右侧额下回三角部之间的FC降低。因此，负责注意力、刺激监测和听觉定向的脑区功能紊乱导致耳鸣的产生。
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