早发型和晚发型小肠腺癌的临床病理比较：一项多中心国际研究。
A Clinicopathologic Comparison Between Early-Onset and Late-Onset Small Bowel Adenocarcinoma: A Multicenter International Study.
机构信息
Unit of Anatomic Pathology, ICS Maugeri-IRCCS SpA SB, Pavia, Italy.
Department of Molecular Medicine, University of Pavia, Pavia, Italy.
出版信息
Am J Gastroenterol. 2024 Mar 1;119(3):576-579. doi: 10.14309/ajg.0000000000002585. Epub 2023 Nov 15.
INTRODUCTION
Early-onset small bowel adenocarcinoma (EO-SBA) is a rare and poorly characterized entity.
METHODS
This retrospective study conducted on an international multicenter cohort of 208 patients with SBA aimed at comparing clinicopathologic features of EO-SBA (age younger than 50 years at SBA diagnosis) and late-onset SBA (age 50 years or older at SBA diagnosis).
RESULTS
The presence of predisposing pathologic conditions was significantly more common in the EO-SBA group compared with that in the late-onset SBA group ( P = 0.003, Fisher exact test; relative risk: 1.50, 95% confidence interval: 1.20-1.86). This difference is mainly due to the significantly higher prevalence of celiac disease among patients with EO-SBA.
DISCUSSION
EO-SBA is strongly associated with predisposing conditions, particularly with celiac disease, highlighting the importance of routine screening for celiac disease in patients with EO-SBA.
简介
早发性小肠腺癌（EO-SBA）是一种罕见且特征不明确的疾病。
方法
本研究对 208 例 SBA 患者的国际多中心队列进行了回顾性研究，旨在比较 EO-SBA（SBA 诊断时年龄<50 岁）和晚发性 SBA（SBA 诊断时年龄≥50 岁）的临床病理特征。
结果
与晚发性 SBA 组相比，EO-SBA 组存在易患性病理情况的比例显著更高（P=0.003，Fisher 确切检验；相对风险：1.50，95%置信区间：1.20-1.86）。这种差异主要归因于 EO-SBA 患者中乳糜泻的患病率明显更高。
讨论
EO-SBA 与易患性疾病密切相关，尤其是乳糜泻，这突出了在 EO-SBA 患者中常规筛查乳糜泻的重要性。
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