Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
Master's Programme Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
Int J Environ Health Res. 2024 Aug;34(8):2947-2956. doi: 10.1080/09603123.2023.2280155. Epub 2023 Nov 15.
The relation of exposure to arsenic in drinking water during pregnancy to the risk of preterm birth (PTB) was contradictory. This meta-analysis aimed to examine the association between drinking water arsenic and PTB. A systematic search in PubMed and Scopus was performed to achieve all relevant studies. Odds ratios (OR) and 95% confidence intervals (CI) were used to pool data using the random-effect models. Overall, 11 studies with a total sample size of 3,404,189 participants were included in the meta-analysis. Arsenic exposure through drinking water during pregnancy was related to an increased risk of PTB (OR = 1.06; 95%CI = 1.01-1.10 for highest versus lowest category of arsenic), with significant heterogeneity across the studies (I = 84.8%, = 0.001). This finding was supported by cohort studies (OR = 1.05; 95%CI = 1.01-1.10). This meta-analysis proposes that higher arsenic exposure in drinking water may be a risk factor for PTB.
怀孕期间饮用水中砷暴露与早产（PTB）风险之间的关系存在争议。本荟萃分析旨在研究饮用水砷与 PTB 之间的关联。系统检索了 PubMed 和 Scopus 以获取所有相关研究。使用随机效应模型使用比值比（OR）和 95％置信区间（CI）来汇总数据。总体而言，共有 11 项研究，总样本量为 3,404,189 名参与者，包括在荟萃分析中。怀孕期间饮用水中的砷暴露与 PTB 风险增加相关（OR=1.06；95％CI=1.01-1.10 最高与最低砷类别），研究之间存在显著异质性（I=84.8％，P=0.001）。队列研究也支持这一发现（OR=1.05；95％CI=1.01-1.10）。本荟萃分析表明，饮用水中更高的砷暴露可能是 PTB 的危险因素。
Cochrane Database Syst Rev. 2017-7-28
Cochrane Database Syst Rev. 2017-11-2
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