疱疹单纯病毒触发 N-甲基-D-天冬氨酸脑炎后复发性抑郁障碍中双相情感障碍的揭示。
Unmasking bipolarity in recurrent depressive disorder following herpes simplex virus triggered n-methyl-D-aspartate encephalitis.
机构信息
Department of Psychiatry, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bangalore, India.
Department of Neurology, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bangalore, India.
出版信息
Bipolar Disord. 2024 Mar;26(2):192-195. doi: 10.1111/bdi.13393. Epub 2023 Nov 16.
OBJECTIVE
Herpes simplex virus (HSV) infection triggered n-methyl-D-aspartate (NMDA) encephalitis can lead to varied neuropsychiatric manifestations, including movement disorders and manic symptoms. HSV is known to affect the same brain regions as in secondary mania.
METHOD
We present a 35-year-old female diagnosed with recurrent depressive disorder (RDD) who developed NMDA encephalitis triggered by HSV infection.
RESULT
HSV-triggered NMDA encephalitis led to a manic switch in a woman with RDD on antidepressants, along with the new onset of dyskinetic movements.
CONCLUSION
A neurological insult predisposed our patient to the variable effects of antidepressant drugs.
目的
单纯疱疹病毒（HSV）感染引发的 N-甲基-D-天冬氨酸（NMDA）脑炎可导致多种神经精神表现，包括运动障碍和躁狂症状。HSV 已知会影响与继发性躁狂相同的大脑区域。
方法
我们介绍了一位 35 岁的女性，她被诊断患有复发性抑郁障碍（RDD），因 HSV 感染引发 NMDA 脑炎。
结果
HSV 引发的 NMDA 脑炎导致正在服用抗抑郁药的 RDD 女性出现躁狂发作，并伴有运动障碍的新发病。
结论
神经损伤使我们的患者易受抗抑郁药物的各种影响。
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