用于正电子发射断层扫描成像神经炎症中集落刺激因子1受体的候选示踪剂：问题与进展
Candidate Tracers for Imaging Colony-Stimulating Factor 1 Receptor in Neuroinflammation with Positron Emission Tomography: Issues and Progress.
作者信息
Altomonte Stefano, Pike Victor W
机构信息
Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Building 10, B3 C346A, 10 Center Drive, Bethesda, Maryland 20892, United States.
出版信息
ACS Pharmacol Transl Sci. 2023 Oct 18;6(11):1632-1650. doi: 10.1021/acsptsci.3c00213. eCollection 2023 Nov 10.
Abstract
The tyrosine kinase, colony-stimulating factor 1 receptor (CSF1R), has attracted attention as a potential biomarker of neuroinflammation for imaging studies with positron emission tomography (PET), especially because of its location on microglia and its role in microglia proliferation. The development of an effective radiotracer for specifically imaging and quantifying brain CSF1R is highly challenging. Here we review the progress that has been made on PET tracer development and discuss issues that have arisen and which remain to be addressed and resolved.
摘要
酪氨酸激酶集落刺激因子1受体（CSF1R）作为神经炎症的潜在生物标志物，已引起正电子发射断层扫描（PET）成像研究的关注，特别是因其位于小胶质细胞上以及在小胶质细胞增殖中的作用。开发一种用于特异性成像和定量脑CSF1R的有效放射性示踪剂极具挑战性。在此，我们综述了PET示踪剂开发方面取得的进展，并讨论了已出现以及仍有待解决的问题。
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