培养的大鼠心肌细胞对葡萄糖和棕榈酸的代谢
Glucose and palmitate metabolism by beating rat heart cells in culture.
作者信息
Frelin C, Pinson A, Athias P, Surville J M, Padieu P
出版信息
Pathol Biol (Paris). 1979 Jan;27(1):45-50.
PMID:379752
Abstract
The metabolism of glucose and palmitate by new born rat heart cell in tissue culture was investigated to ascertain the usefulness of this model system for metabolic studies. Heart cells in culture oxidize palmitate at a rate which is close to the rate reported in vivo. The fate of glucose is shown to differ from in vivo. High rates of lactate release are observed although there are many evidences that cells are not hypoxic. This impaired regulation is likely due to an impaired uptake of glucose.
摘要
为了确定这种模型系统在代谢研究中的实用性，对组织培养中新生大鼠心脏细胞的葡萄糖和棕榈酸代谢进行了研究。培养的心脏细胞氧化棕榈酸的速率与体内报道的速率相近。结果表明，葡萄糖的代谢命运与体内情况不同。尽管有许多证据表明细胞并非缺氧，但仍观察到较高的乳酸释放率。这种调节受损可能是由于葡萄糖摄取受损所致。
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