短期低水平暴露于空气污染物对老年肺部脓毒症患者住院的影响。
Impacts of short-term low-level exposure to air pollutants on hospital admissions for pulmonary sepsis in elderly patients.
机构信息
Emergency Department, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, 518020, Guangdong, China.
Shenzhen National Climate Observatory, Meteorological Bureau of Shenzhen Municipality, Shenzhen, Guangdong, China.
出版信息
BMC Pulm Med. 2023 Nov 17;23(1):448. doi: 10.1186/s12890-023-02652-9.
BACKGROUND
Acute exposures to high levels of air pollutants are thought to be associated with hospitalization of patients with lung infection, while relatively little is known about the association between air pollutants and HOSPITAL ADMISSIONS FOR pulmonary sepsis.
OBJECTIVES
To assess the correlation between low-level exposure to air pollutants and the hospitalizations for pulmonary sepsis in elderly patients.
METHODS
A total of 249 elderly patients with pulmonary sepsis from January 2018 to December 2020 in Shenzhen people's hospital were included. The data regarding hospitalizations for pulmonary sepsis, meteorological factors, and daily average levels of air pollutants on single-day lags (Lag0 to Lag7) in Shenzhen were collected. Low-level exposure was defined as the annual means of air pollutants below the levels of the Ambient Air Quality Standard (AAQS) in China (NO. GB3095-2012) and/or Global Air Quality Guidelines (AQG). A time-stratified case-crossover study design approach was used to evaluate the associations between exposure to air pollutants and incidence of the disease, univariate and multivariate logistic regression analysis to analyze the association between levels of air pollutants and hospitalizations for pulmonary sepsis in elderly patients.
RESULTS
Exposure to PM(P = 0.007, Lag 2 day; P = 0.038, Lag6 day), PM(P = 0.046, Lag2 day), PM(P = 0.048, Lag4 day), and O(P = 0.044, Lag6 day) was positively correlated with elevated risk of hospitalizations for pulmonary sepsis. In addition, logistic regression analysis revealed that exposure to PM (OR = 1.833, 95%CI:1.032 ~ 3.256, Lag6 day) and O (OR = 2.091, 95%CI:1.019 ~ 4.289, Lag6 day) were the independent risk factors of pulmonary sepsis in elderly patients.
CONCLUSION
Our results demonstrate that short-term low-level exposure to PM and O could elevate the risk of hospitalizations for pulmonary sepsis in elderly patients in Shenzhen, providing evidence for developing early warning and screening systems for pulmonary sepsis.
背景
人们认为急性暴露于高水平的空气污染物与肺部感染患者的住院有关，而对于空气污染物与肺部败血症住院之间的关系则知之甚少。
目的
评估低水平空气污染物暴露与老年患者肺部败血症住院之间的相关性。
方法
纳入 2018 年 1 月至 2020 年 12 月在深圳市人民医院住院的 249 例老年肺部败血症患者。收集了肺部败血症住院数据、气象因素以及深圳单日滞后（Lag0 至 Lag7）的空气污染物日平均水平数据。低水平暴露定义为低于中国（GB3095-2012 号）和/或全球空气质量指南（AQG）环境空气质量标准（AAQS）水平的空气污染物年平均水平。采用时间分层病例交叉研究设计方法评估空气污染物暴露与疾病发生之间的关联，单变量和多变量逻辑回归分析分析空气污染物水平与老年患者肺部败血症住院之间的关联。
结果
暴露于 PM（P=0.007，Lag2 天；P=0.038，Lag6 天）、PM（P=0.046，Lag2 天）、PM（P=0.048，Lag4 天）和 O（P=0.044，Lag6 天）与肺部败血症住院风险升高呈正相关。此外，逻辑回归分析显示，暴露于 PM（OR=1.833，95%CI：1.0323.256，Lag6 天）和 O（OR=2.091，95%CI：1.0194.289，Lag6 天）是老年患者肺部败血症的独立危险因素。
结论
我们的结果表明，短期低水平暴露于 PM 和 O 可能会增加深圳老年患者肺部败血症住院的风险，为开发肺部败血症早期预警和筛查系统提供了证据。
Zotero 插件